Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change

• Published in: Circulation (New York, N.Y.) Vol. 112; no. 3; pp. 384 - 386
• Main Authors: KAMIYA, Atsunori, KAWADA, Toru, YAMAMOTO, Kenta, MICHIKAMI, Daisaku, ARIUMI, Hideto, MIYAMOTO, Tadayoshi, UEMURA, Kazunori, SUGIMACHI, Masaru, SUNAGAWA, Kenji
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 19.07.2005
• Subjects: Animals; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Blood vessels and receptors; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fundamental and applied biological sciences. Psychology; General aspects; Heart - innervation; Kidney - innervation; Medical sciences; Muscles - innervation; Nitroprusside - pharmacology; Phenylephrine - pharmacology; Pressoreceptors - physiology; Rabbits; Sympathetic Nervous System - physiology; Vertebrates: cardiovascular system; Sympathetic nerve; catecholamines; muscles; Autonomic nervous system; nervous system, autonomic; Cardiovascular disease; nervous system, sympathetic; Baroreceptor; Sympathetic nervous system
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.104.493338

Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 microg/kg) followed by phenylephrine (3 microg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96+/-0.01, mean+/-SE) and cardiac (r=0.96+/-0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97+/-0.01) and cardiac (r=0.97+/-0.01) SNAs in experiment 2 (baroreflex open-loop condition). Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.