EV71 vaccination impact on the incidence of encephalitis in patients with hand, foot and mouth disease

• Published in: Human vaccines & immunotherapeutics Vol. 17; no. 7; pp. 2097 - 2100
• Main Authors: Li, Jian, Yin, Xiuzhi, Lin, Aiwei, Nie, Xiuzhen, Liu, Liyan, Liu, Shihua, Li, Na, Wang, Ping, Song, Shuangshuang, Wang, Shaoning, Xu, Daoyan
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.07.2021; Taylor & Francis Group
• Subjects: China; encephalitis; Encephalitis - epidemiology; Encephalitis - prevention & control; Enterovirus A, Human; EV71 vaccine; foot and mouth disease; hand; Hand, Foot and Mouth Disease - epidemiology; Hand, Foot and Mouth Disease - prevention & control; Humans; Incidence; Infant; protective effect; Short Report; Vaccination; China; foot and mouth disease; EV71 vaccine; encephalitis; protective effect; hand
• ISSN: 2164-5515; 2164-554X
• DOI: 10.1080/21645515.2020.1851129

In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in non-vaccinated (P = .028), which suggests that EV71 vaccine has a protective effect on the occurrence of encephalitis. But some EV71 vaccinated patients still developed into encephalitis showed that they had not produced protection or protection was weak against EV71-related encephalitis; the reasons require further investigation.