Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease

• Published in: Journal of the neurological sciences Vol. 208; no. 1; pp. 17 - 24
• Main Authors: Kobayashi, Katsuji, Nakano, Hiroyuki, Hayashi, Masahiro, Shimazaki, Masao, Fukutani, Yuken, Sasaki, Kazuo, Sugimori, Kaoru, Koshino, Yoshifumi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15.04.2003; Elsevier Science
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Antibodies, Monoclonal - metabolism; Apoptosis; Apoptosis - physiology; Biological and medical sciences; Brain - anatomy & histology; Brain - metabolism; Brain - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Epitopes - immunology; Epitopes - metabolism; Humans; Immunohistochemistry; In Situ Nick-End Labeling - methods; Medical sciences; Neurofibrillary tangles; Neurofibrillary Tangles - metabolism; Neurology; Neurons - pathology; Peptide Fragments - metabolism; Phosphorylation; Pretangle neurons; tau Proteins - metabolism; tau Proteins - physiology; TUNEL; Neurofibrillary tangles; TUNEL; Pretangle neurons; Alzheimer's disease; Apoptosis; Human; Immunohistochemistry; Nervous system diseases; Phosphorylation; Pathophysiology; Alzheimer disease; Neurofibrillary tangle; Cerebral disorder; Pathology; Neuron; Tau protein; Central nervous system disease; Degenerative disease

In addition to neuritic changes and amyloid deposits, neuronal and glial cell apoptosis is an important pathological feature of Alzheimer's disease (AD). Several factors have been postulated as causes or triggers of cellular apoptotic change. This study focused on a quantifiable relationship be...