Serum total adiponectin level and the risk of cardiovascular disease in general population: A meta-analysis of 17 prospective studies

• Published in: Atherosclerosis Vol. 228; no. 1; pp. 29 - 35
• Main Authors: Hao, Guang, Li, Wei, Guo, Rui, Yang, Jin-Gang, Wang, Yang, Tian, Yu, Liu, Man-Yun, Peng, Ya-Guang, Wang, Zeng-Wu
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.05.2013
• Subjects: Adiponectin; Adiponectin - blood; atherosclerosis; blood serum; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; confidence interval; coronary disease; Coronary heart disease; epidemiological studies; Humans; Meta-Analysis; Prospective Studies; relative risk; Risk Factors; Stroke; Cardiovascular disease; Meta-Analysis; Stroke; Coronary heart disease; Adiponectin
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2013.02.018

Abstract Objective Many studies have assessed the association between serum adiponectin and the risk of cardiovascular disease (CVD), yet whether adiponectin is an independent risk factor for CVD remains controversial. We performed a meta-analysis of 17 prospective epidemiologic studies to evaluate this relationship in the general population. Methods PubMed and Embase databases were searched through June 2012 to identify studies meeting a priori inclusion criteria, in addition to conducting a secondary reference review. Two principle investigators respectively extracted the information with either fixed-effect model or random-effect model to calculate the relationship between adiponectin and the risk of CVD. Results We summarized 17 prospective studies with a total of 23,717 participants. Overall, higher serum adiponectin was related to an increased risk of ischemic stroke: pooled risk ratio (RR) of 1.34 [95% confidence intervals (CI): 1.06–1.69] with no heterogeneity ( Q  = 1.23; P  = 0.541). Serum adiponectin was not related to coronary heart disease (CHD) or CVD: pooled RR of 0.96 (95% CI: 0.85–1.08) and 1.00 (95% CI: 0.89–1.13), respectively. Conclusions Increased serum adiponectin was related to an elevated risk of ischemic stroke, but there was no clear evidence indicating a positive relationship between adiponectin and the risk of CHD or CVD.