Pathogenicity and virulence of hepatitis A virus

Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form. The reason for these diff...

Full description

Saved in:
Bibliographic Details
Published inVirulence Vol. 12; no. 1; pp. 1174 - 1185
Main Authors Pintó, Rosa M, Pérez-Rodríguez, Francisco-Javier, Costafreda, Maria-Isabel, Chavarria-Miró, Gemma, Guix, Susana, Ribes, Enric, Bosch, Albert
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.12.2021
Taylor & Francis Group
Subjects
Child
codon usage
CpG
genomic composition
HAV
Hepatitis A
Hepatitis A virus - genetics
Humans
IRES
naked virions
quasi-enveloped virions
Review
Virulence
naked virions
IRES
quasi-enveloped virions
genomic composition
CpG
HAV
codon usage
Online AccessGet full text

Cover

More Information
Summary:Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form. The reason for these different outcomes is unknown, but it is generally accepted that host factors such as the immunological status, age and the occurrence of underlaying hepatic diseases are the main determinants of the severity. However, it cannot be ruled out that some virus traits may also contribute to the severe clinical outcomes. In this review, we will analyze which genetic determinants of the virus may determine virulence, in the context of a paradigmatic virus in terms of its genomic, molecular, replicative, and evolutionary features.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2150-5594
2150-5608
DOI:10.1080/21505594.2021.1910442