A prospective study to compare the measured glomerular filtration rate compared to estimated glomerular filtration rate in patients undergoing definitive chemoradiation, with platinum agents for various malignancies

• Published in: Journal of cancer research and therapeutics Vol. 15; no. 8; pp. 56 - 59
• Main Authors: Rudresh, A.H, Asati, Vikas, Lakshmaiah, K.C, Lokanatha, D, Babu, Suresh, Rajeev, L.K, Lokesh, K.N, Babu, Govind
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.03.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Subjects: Acetic acid; Adult; Age; Age Factors; Aged; Antineoplastic agents; Cancer; Cancer patients; Carboplatin; Chemoradiotherapy - adverse effects; Chemoradiotherapy - methods; Chemotherapy; Cisplatin - administration & dosage; Cisplatin - adverse effects; Comparative analysis; Female; Glomerular filtration rate; Glomerular Filtration Rate - drug effects; Head & neck cancer; Health aspects; Humans; Kidney - drug effects; Kidney - physiopathology; Male; Medical imaging; Medical research; Middle Aged; Neoplasms - blood; Neoplasms - therapy; Oncology; Organic acids; Platinum compounds; Prospective Studies; Radiation therapy; Radiation-Sensitizing Agents - administration & dosage; Radiation-Sensitizing Agents - adverse effects; Radioisotopes; Radionuclide Imaging - methods; Radiopharmaceuticals - administration & dosage; Statistical analysis; Technetium Tc 99m Pentetate - administration & dosage; Treatment Outcome; Denmark; India; estimated glomerular filtration rate; cisplatin; Cockcroft-Gault formula; Chemoradiation; measured glomerular filtration rate; Cockcroft–Gault formula
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/0973-1482.204881

Context: Renal function assessment is of paramount importance before using the platinum agents especially cisplatin. Glomerular filtration rate (GFR) estimation by diethyl-triamine-penta-acetic acid (DTPA) scan (measured GFR [mGFR]) is considered gold standard. Aims: The aim of this study is to know if we can replace the mGFR with the GFR estimation with Cockcroft-Gault formula (eGFR) in patients undergoing chemoradiation. Settings and Design: This is a prospective, descriptive study. Subjects and Methods: Patients who are planned for definitive chemoradiation will be eligible for the study. Renal function will be measured DTPA scan and Cockcroft-Gault (CG) formula. Subgroup analysis based on the weight, age, and sex will be done. Statistical Analysis Used: Demographic and renal function parameters were analyzed using summary measures. To test the significance of the difference between mGFR and cGFR, a paired t-test will be used; to look for an association between various estimates of renal function, the Pearson's correlation coefficient will be calculated using a two-tailed test. Results: Median mGFR of patients was 82.7 (range: 65-125 ml/min, standard deviation [SD] =14.0 ml/min) while the median eGFR as per the CG formula was 83.9 ml/min (range: 37-137 ml/min, SD = 24.4 ml/min). The median mGFR was only 1.2 ml/min lesser when measures by the CG formula with no significance difference between them (P = 0.66, 95% confidence interval: −4.5-6.3). Conclusions: We concluded that in resource-limited setting eGFR using CG formula can replace mGFR, especially in patients with age <60 years. Although weight did not showed a significant difference by two methods, a study with large sample is needed to confirm the result.