The effects of antifungal stewardship programs at a tertiary-care teaching hospital in Japan

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 25; no. 6; pp. 458 - 462
• Main Authors: Kawaguchi, Hiroshi, Yamada, Koichi, Imoto, Waki, Yamairi, Kazushi, Shibata, Wataru, Namikawa, Hiroki, Yoshii, Naoka, Nakaie, Kiyotaka, Okada, Yasuyo, Fujita, Akiko, Shinoda, Yoshikatsu, Nakamura, Yasutaka, Kaneko, Yukihiro, Nagayama, Katsuya, Kakeya, Hiroshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2019
• Subjects: Antifungal stewardship programs (AFSPs); Candidemia; Days of therapy per 1000 patient-days; Defined daily doses per 1000 patient-days; Days of therapy per 1000 patient-days; Antifungal stewardship programs (AFSPs); Candidemia; Defined daily doses per 1000 patient-days
• ISSN: 1341-321X; 1437-7780
• DOI: 10.1016/j.jiac.2019.01.015

Patients with invasive fungal diseases (IFDs) generally have a high mortality rate, and resistance to antifungal drugs and the high costs associated with it have led to recent problems, necessitating the appropriate use of antifungals. To this end, we launched Antifungal Stewardship Programs (AFSPs) in our hospital. Patients who were systemically administered antifungals from January 2011 to December 2016 were enrolled this study and divided into pre-intervention and intervention groups. No significant difference was observed in defined daily doses per 1000 patient-days (23.3 ± 8.0 vs 20.4 ± 10.8, p = 0.251) between the groups. The monthly average for the days of therapy per 1000 patient-days was significantly lower in the intervention group (15.1 ± 3.1 vs 12.7 ± 4.3, p = 0.009). The cost of the antifungals reduced over the 3-year period by $260,520 (13.5%). Furthermore, a decreasing trend was observed in both the 30-day mortality (40.9% vs 30.0%, p = 0.414) and in-hospital mortality (63.6% vs 36.7%, p = 0.054) in patients with candidemia. Our results indicate that AFSPs are efficacious and cost-effective approaches.