Abnormal speech articulation, psychomotor retardation, and subcortical dysfunction in major depression

• Published in: Journal of psychiatric research Vol. 27; no. 3; pp. 309 - 319
• Main Authors: Flint, Alistair J., Black, Sandra E., Campbell-Taylor, Irene, Gailey, Gillian F., Levinton, Carey
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.07.1993; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Articulation Disorders - diagnosis; Articulation Disorders - physiopathology; Articulation Disorders - psychology; Biological and medical sciences; Corpus Striatum - physiopathology; Depression; Depressive Disorder - diagnosis; Depressive Disorder - physiopathology; Depressive Disorder - psychology; Dopamine - physiology; Female; Humans; Male; Medical sciences; Middle Aged; Mood disorders; Neurologic Examination; Parkinson Disease - diagnosis; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Phonetics; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychomotor Disorders - diagnosis; Psychomotor Disorders - physiopathology; Psychomotor Disorders - psychology; Psychopathology. Psychiatry; Sound Spectrography; Speech Intelligibility - physiology; Speech Production Measurement; Substantia Nigra - physiopathology; Articulation; Human; Mood disorder; Language; Pathophysiology; Acoustic spectrum; Central nervous system; Depression; Dopaminergic pathway; Nigrostriatal pathway; Brain (vertebrata)
• ISSN: 0022-3956; 1879-1379
• DOI: 10.1016/0022-3956(93)90041-Y

Psychomotor retardation, characterized by changes in speech, motility and cognition, is common in major depression. It is also a cardinal feature of subcortical disorders such as Parkinson's disease (PD). Based on this observation ans other data it has been hypothesized that the retardation of depression is related to mesolimbic-nigrostriatal dysfunction. To further test this hypothesis, speech articulation in major depression was compared to that in PD, where disordered articulation is related to bradykinesia and rigidity caused by striatal dopamine depletion. Thirty subjects with major depression were compared with 30 patients with PD and 31 normal controls on 3 acoustic measures of articulation. Major depression and PD groups had significantly shortened voice onset time and decreased second formant transition compared to controls, and major depression also had increased spirantization. There were no differences between the depression and PD groups on any of the acoustic measures. These findings provide indirect support for the hypothesis that nigrostriatal dysfunction is related to psychomotor slowing in major depression.