HPLC-studies on nonmercapt-mercapt conversion of human serum albumin

Human mercaptalbumin (HMA) and nonmercaptalbumin (HNA) could be separated by high-performance liquid chromatography (HPLC) at neutral pH. Using HPLC, the present authors found the nonmercapt-mercapt conversion (HNA---HMA) during hemodialysis and the mercapt-nonmercapt conversion (HMA---HNA) after he...

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Bibliographic Details
Published inInternational journal of peptide and protein research Vol. 25; no. 4; p. 398
Main Authors Sogami, M, Era, S, Nagaoka, S, Kuwata, K, Kida, K, Miura, K, Inouye, H, Suzuki, E, Hayano, S, Sawada, S
Format Journal Article
LanguageEnglish
Published Denmark 01.04.1985
Subjects
Chromatography, High Pressure Liquid
Humans
Kidney Failure, Chronic - blood
Renal Dialysis
Serum Albumin - analysis
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Summary:Human mercaptalbumin (HMA) and nonmercaptalbumin (HNA) could be separated by high-performance liquid chromatography (HPLC) at neutral pH. Using HPLC, the present authors found the nonmercapt-mercapt conversion (HNA---HMA) during hemodialysis and the mercapt-nonmercapt conversion (HMA---HNA) after hemodialysis in chronic renal failure, indicating HMA as the covalent carrier protein for sulfur-containing amino acids.
ISSN:0367-8377
DOI:10.1111/j.1399-3011.1985.tb02191.x