Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder
Objective It is suggested that age at onset (AAO) of bipolar I disorder (BP‐I) is decreasing. We tested for a birth‐cohort effect on AAO using admixture analysis. Method A clinical sample of 3896 BP‐I cases was analysed using two approaches: (i) in a subsample with untruncated AAO × birth year distr...
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Published in | Acta psychiatrica Scandinavica Vol. 133; no. 3; pp. 205 - 213 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.03.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
It is suggested that age at onset (AAO) of bipolar I disorder (BP‐I) is decreasing. We tested for a birth‐cohort effect on AAO using admixture analysis.
Method
A clinical sample of 3896 BP‐I cases was analysed using two approaches: (i) in a subsample with untruncated AAO × birth year distribution (n = 1865), we compared the best‐fitting model for the observed AAO in patients born ≤1960 and >1960, (ii) to control for potential confounders, two separate subsamples born ≤1960 and >1960 were matched for age at interview (n = 250), and a further admixture analysis was undertaken.
Results
The two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP‐I cases born >1960.
Conclusion
The decrease in AAO of BP‐I in recent birth‐cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania. |
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Bibliography: | Swiss National Science Foundation - No. 32-40677.94; No. 32-049746.96 Institut National de la Santé et de la Recherche Médicale (INSERM) Assistance Publique-Hôpitaux de Paris - No. CRC 94232 Ministère de la Recherche (PHRC) - No. AOM98152 Fondation FondaMental istex:D08362192F964FB95BCE10C658D56BD571413896 ark:/67375/WNG-6520W3P3-X ArticleID:ACPS12478 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0001-690X 1600-0447 |
DOI: | 10.1111/acps.12478 |