Oligofructose modulates lipid metabolism alterations induced by a fat-rich diet in rats

• Published in: Journal of applied toxicology Vol. 18; no. 1; pp. 47 - 53
• Main Authors: Kok, Nadine N., Taper, Henryk S., Delzenne, Nathalie M.
• Format: Journal Article
• Language: English
• Published: Chichester John Wiley & Sons, Ltd 01.01.1998; Wiley
• Subjects: Animals; Biological and medical sciences; Body Weight - drug effects; cholesterol; Cholesterol - blood; Corn Oil - administration & dosage; Dietary Fats - administration & dosage; Dietary Fats - toxicity; Fatty Acid Synthases - metabolism; Feces - chemistry; Feeding. Feeding behavior; Fructans - pharmacology; Fundamental and applied biological sciences. Psychology; high-fat diet; Lipid Metabolism; Lipids - blood; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; oligofructose; Oligosaccharides - pharmacology; Organ Size - drug effects; Phospholipids - blood; Phospholipids - metabolism; Rats; Rats, Wistar; triglycerides; Triglycerides - blood; Triglycerides - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Rat; Ketose; Liver; Rodentia; Oligoholoside; Lipids; Supplemented diet; Metabolism; Triglyceride; Cholesterol; Feeding; Prevention; Vertebrata; Mammalia; Triacylglycerol; Animal; Fat; Dietary fiber
• ISSN: 0260-437X; 1099-1263
• DOI: 10.1002/(SICI)1099-1263(199801/02)18:1<47::AID-JAT474>3.0.CO;2-S

The aim of this study was to test the hypothesis that non‐digestible fructans, namely oligofructose (OFS), are able to decrease post‐prandial lipaemia in rats fed a high‐fat diet composed of 10% lard, 4% corn oil and 0.15% cholesterol. Male Wistar rats were divided into three groups: group 1 was fed a standard low‐fat diet (AO4), group 2 received the high‐fat diet (HF) and group 3 received 10% (w/w) OFS in the HF diet (HF‐OFS) for 3 weeks. The OFS supplementation reduced post‐prandial triglyceridaemia by more than 50%, compared to both AO4 and HF groups. It also protected rats against the increase in free cholesterol serum level induced by the HF diet. The OFS did not prevent the HF‐induced hepatic accumulation of triglycerides, phospholipids and cholesterol; however, histochemical analysis showed smaller lipid droplets in the liver of HF‐OFS rats as compared to HF rats. Our results suggest that, when given in HF diet, OFS decreases serum triglycerides through an extra‐hepatic event, namely by enhancing triglyceride‐rich lipoprotein catabolism. © 1998 John Wiley & Sons, Ltd.