Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease

• Published in: Neuropathology and applied neurobiology Vol. 37; no. 7; pp. 791 - 802
• Main Authors: Orimo, S., Uchihara, T., Kanazawa, T., Itoh, Y., Wakabayashi, K., Kakita, A., Takahashi, H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2011; Blackwell
• Subjects: Aged; Aged, 80 and over; Axons - pathology; Biological and medical sciences; cardiac sympathetic nerve; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Heart - innervation; Humans; incidental Lewy body disease; Lewy Body Disease - pathology; Male; Medical sciences; Middle Aged; myelinated axon; Nerve Degeneration - pathology; Nerve Fibers, Myelinated - pathology; Nerve Fibers, Unmyelinated - pathology; Neurology; Parkinson Disease - pathology; Parkinson's disease; unmyelinated axon; α-synuclein; Nervous system diseases; Parkinson's disease; unmyelinated axon; Lewy body disease; Parkinson disease; Cardiovascular disease; Axon; Sympathetic nervous system; myelinated axon; Cerebral disorder; Autonomic nervous system; incidental Lewy body disease; Heart disease; Central nervous system disease; Lewy body dementia; cardiac sympathetic nerve; Degenerative disease; Degeneration; α-synuclein; Extrapyramidal syndrome
• ISSN: 0305-1846; 1365-2990
• DOI: 10.1111/j.1365-2990.2011.01194.x

S. Orimo, T. Uchihara, T. Kanazawa, Y. Itoh, K. Wakabayashi, A. Kakita and H. Takahashi (2011) Neuropathology and Applied Neurobiology37, 791–802 Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease Aims: We recently demonstrated accumulation of α‐synuclein aggregates of the cardiac sympathetic nerve in Parkinson's disease (PD) and a possible relationship between degeneration of the cardiac sympathetic nerve and α‐synuclein aggregates. The aim of this study is to determine whether there is a difference in the degenerative process between unmyelinated and myelinated axons of the cardiac nerve. Methods: We immunohistochemically examined cardiac tissues from four pathologically verified PD patients, nine patients with incidental Lewy body disease (ILBD) and five control subjects, using antibodies against neurofilament, myelin basic protein (MBP) and α‐synuclein. First, we counted the number of neurofilament‐immunoreactive axons not surrounded by MBP (unmyelinated axons) and those surrounded by MBP (myelinated axons). Next, we counted the number of unmyelinated and myelinated axons with α‐synuclein aggregates. Results: (i) The percentage of unmyelinated axons in PD (77.5 ± 9.14%) was significantly lower compared to that in control subjects (92.2 ± 2.40%). (ii) The ratio of unmyelinated axons with α‐synuclein aggregates to total axons with α‐synuclein aggregates in ILBD ranged from 94.4 to 100 (98.2 ± 2.18%). Among axons with α‐synuclein aggregates, unmyelinated axons were the overwhelming majority, comprising 98.2%. Conclusion: These findings suggest that in PD unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve, because α‐synuclein aggregates accumulate much more abundantly in unmyelinated axons.