4-METHOXYBENZYLOXYCARBONYL AMINO-ACIDS IN SOLID-PHASE PEPTIDE-SYNTHESIS

Moz-amino acids were used in solid-phase synthesis of Leu-Ala-Gly-Val and thymosin .alpha.1. It was found that the Moz-group can be removed rapidly and completely with 5-10% TFA in CH2Cl2. Some advantages of utilizing Moz-amino acids over Boc-amino acids in solid phase peptide synthesis are demonstr...

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Bibliographic Details
Published inInternational journal of peptide and protein research Vol. 30; no. 5; pp. 662 - 667
Main Authors WANG, SS, CHEN, ST, WANG, KT, MERRIFIELD, RB
Format Journal Article
LanguageEnglish
Published FREDERIKSBERG C Wiley 01.11.1987
Subjects
Biochemistry & Molecular Biology
Chromatography, High Pressure Liquid
Life Sciences & Biomedicine
Peptides - chemical synthesis
Science & Technology
Thymalfasin
Thymosin - analogs & derivatives
Thymosin - chemical synthesis
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Summary:Moz-amino acids were used in solid-phase synthesis of Leu-Ala-Gly-Val and thymosin .alpha.1. It was found that the Moz-group can be removed rapidly and completely with 5-10% TFA in CH2Cl2. Some advantages of utilizing Moz-amino acids over Boc-amino acids in solid phase peptide synthesis are demonstrated.
ISSN:0367-8377
DOI:10.1111/j.1399-3011.1987.tb03377.x