CD146 as a new marker for an increased chondroprogenitor cell sub-population in the later stages of osteoarthritis

• Published in: Journal of orthopaedic research Vol. 33; no. 1; pp. 84 - 91
• Main Authors: Su, Xinlin, Zuo, Wei, Wu, Zhihong, Chen, Jun, Wu, Nan, Ma, Pei, Xia, Zenan, Jiang, Chao, Ye, Zixing, Liu, Sen, Liu, Jiaqi, Zhou, Guangqian, Wan, Chao, Qiu, Guixing
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2015
• Subjects: Adult; Aged; Arthroplasty, Replacement, Knee; Biomarkers - metabolism; Case-Control Studies; CD146; CD146 Antigen - metabolism; Cell Differentiation; Cells, Cultured; Chondrocytes - metabolism; Chondrocytes - pathology; chondrogenesis; chondroprogenitors; Disease Progression; Female; Femur - metabolism; Femur - pathology; Femur - surgery; Humans; Immunophenotyping; Knee Joint - metabolism; Knee Joint - pathology; Knee Joint - surgery; Male; Middle Aged; osteoarthritis; Osteoarthritis, Knee - metabolism; Osteoarthritis, Knee - pathology; Severity of Illness Index; Stem Cells - metabolism; Stem Cells - pathology; chondroprogenitors; chondrogenesis; CD146; osteoarthritis

Cartilage‐derived mesenchymal stem cells (MSCs) have been isolated with different methods. In this study lateral and medial femoral condyles were respectively collected from patients with late‐stage osteoarthritis during the total knee arthroplasty. After digestion of the cartilage tissues with type...