Kawasaki disease with persistent severe psoriatic-like skin manifestations and sudden cardiac death

This case report describes a 1.3-year-old infant with an atypical presentation of Kawasaki Disease (KD) following exposure to COVID-19 within the family and positive SARS-CoV-2 IgG antibodies. The clinical course was marked by significant left ventricular (LV) dysfunction, progressive coronary arter...

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Bibliographic Details
Published inInternational journal of cardiology congenital heart disease Vol. 21; p. 100604
Main Authors Salih, Aso F., Qadir, Trifa M., Dahdah, Nagib
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2025
Elsevier
Subjects
Aspirin
Atypical
Cardiovascular
Coronary artery aneurysm
IVIG
Kawasaki disease
Pediatric vasculitis
Psoriatic-like skin lesion
Steroids
Sudden death
Warfarin
Psoriatic-like skin lesion
Warfarin
Aspirin
Kawasaki disease
Sudden death
IVIG
Atypical
Pediatric vasculitis
Coronary artery aneurysm
Steroids
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Summary:This case report describes a 1.3-year-old infant with an atypical presentation of Kawasaki Disease (KD) following exposure to COVID-19 within the family and positive SARS-CoV-2 IgG antibodies. The clinical course was marked by significant left ventricular (LV) dysfunction, progressive coronary artery involvement, and complicated by severe dermatologic manifestations including Steven-Johnson-like lesions and psoriatic-like eruptions. Despite initial improvement in cardiac function, the infant developed multiple coronary aneurysms and succumbed to sudden cardiac death. This case highlights the diagnostic and therapeutic challenges in managing atypical KD in the context of COVID-19. We describe the case and review the literature related to the associated severe skin lesions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2666-6685
2666-6685
DOI:10.1016/j.ijcchd.2025.100604