Primary Motor Cortex Reports Efferent Control of Vibrissa Motion on Multiple Timescales

• Published in: Neuron (Cambridge, Mass.) Vol. 72; no. 2; pp. 344 - 356
• Main Authors: Hill, Daniel N., Curtis, John C., Moore, Jeffrey D., Kleinfeld, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.10.2011; Elsevier Limited
• Subjects: Action Potentials - physiology; Animals; Behavior; Female; Motor Cortex - physiology; Neurons; Neurons - physiology; Probability distribution; Rats; Rats, Long-Evans; Somatosensory Cortex - physiology; Vibrissae - innervation; Vibrissae - physiology
• ISSN: 0896-6273; 1097-4199
• DOI: 10.1016/j.neuron.2011.09.020

Exploratory whisking in rat is an example of self-generated movement on multiple timescales, from slow variations in the envelope of whisking to the rapid sequence of muscle contractions during a single whisk cycle. We find that, as a population, spike trains of single units in primary vibrissa motor cortex report the absolute angle of vibrissa position. This representation persists after sensory nerve transection, indicating an efferent source. About two-thirds of the units are modulated by slow variations in the envelope of whisking, while relatively few units report rapid changes in position within the whisk cycle. The combined results from this study and past measurements, which show that primary sensory cortex codes the whisking envelope as a motor copy signal, imply that signals present in both sensory and motor cortices are necessary to compute angular coordinates based on vibrissa touch. ► Populations of neurons can encode intended vibrissa position in motor cortex ► Envelope of vibrissa motion is coded separately from the rhythmic phase ► Signaling contrast with vibrissa sensory cortex, where primarily phase is encoded ► Motor signals are required to represent touch in body-centered coordinates