The role of microRNAs in B-cell development and function

• Published in: Cellular & molecular immunology Vol. 10; no. 2; pp. 107 - 112
• Main Authors: Li, Jingyi, Wan, Ying, Ji, Qing, Fang, Yongfei, Wu, Yuzhang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2013; Nature Publishing Group
• Subjects: Animals; Antibodies; Apoptosis; Apoptosis - genetics; Apoptosis - immunology; Autoimmune diseases; B-Lymphocyte Subsets - cytology; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; Biomedical and Life Sciences; Biomedicine; Cell differentiation; Cell Differentiation - genetics; Cell Differentiation - immunology; Cell fate; Drug Delivery Systems - methods; Gene silencing; Humans; Immunology; Lymphocytes B; Medical Microbiology; Microbiology; MicroRNAs - genetics; MicroRNAs - physiology; miRNA; Review; RNA, Messenger - metabolism; Vaccine; 免疫功能; 基因沉默; 小分子RNA; 微小RNA; 生物过程; 细胞发育; 自身免疫性疾病; B cell; microRNA; development; function
• ISSN: 1672-7681; 2042-0226; 2042-0226
• DOI: 10.1038/cmi.2012.62

MicroRNA （miRNA）-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases.