Foot-and-mouth disease marker vaccine: Cattle protection with a partial VP1 G–H loop deleted virus antigen

• Published in: Vaccine Vol. 29; no. 46; pp. 8405 - 8411
• Main Authors: Fowler, V.L, Bashiruddin, J.B, Maree, F.F, Mutowembwa, P, Bankowski, B, Gibson, D, Cox, S, Knowles, N, Barnett, P.V
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 26.10.2011; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; antibodies; Antibodies, Viral - blood; Applied microbiology; Biological and medical sciences; Cattle; Cattle Diseases - pathology; Cattle Diseases - prevention & control; enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; feet; Foot & mouth disease; Foot-and-mouth disease; Foot-and-Mouth Disease - pathology; Foot-and-Mouth Disease - prevention & control; Foot-and-Mouth Disease Virus - immunology; Fundamental and applied biological sciences. Psychology; Immunization; lesions (animal); Marker vaccine; Medical research; Microbiology; Mortality; swine; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Marker - administration & dosage; Vaccines, Marker - genetics; Vaccines, Marker - immunology; viral antigens; Viral Vaccines - administration & dosage; Viral Vaccines - genetics; Viral Vaccines - immunology; viruses; VP1 G–H loop; Marker vaccine; Foot-and-mouth disease; VP1 G–H loop; Foot and mouth disease; Bovine; Vaccine; VP1 G-H loop; Infection; Antigen; Vertebrata; Mammalia; Viral disease; Artiodactyla; Veterinary; Ungulata
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.08.035

Highlights ► We have demonstrated that the VP1 G–H loop of FMDV is not necessary for protection in cattle. ► We have demonstrated that an FMD virus lacking the VP1 G–H loop can be used as an effective marker vaccine. ► We demonstrate that subclinical infection can be easily and rapidly diagnosed in cattle vaccinated with this negative marker vaccine using our associated diagnostic test.