Relationship Between Subclinical Cardiovascular Diseases and Cardiac Morpho-Functional Parameters in Preclinical Stage A/B Heart Failure Adults with Type 2 Diabetes

• Published in: Diabetes, metabolic syndrome and obesity Vol. 15; pp. 3923 - 3931
• Main Authors: Xiao, Yan, Yao, Xin-Yue, Wang, Yong-Hui, Han, Lan-Wen, Li, Lian-Xia, Li, Ming, Gao, Shan
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2022; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Adults; Alcohol use; Analysis; Angina pectoris; Blood pressure; Cardiovascular disease; Carotid arteries; Coronary heart disease; Diabetes; Diagnostic imaging; echocardiography; Fasting; Flow velocity; Heart failure; Insulin resistance; Medical prognosis; Medical research; Medicine, Experimental; Normal distribution; Original Research; preclinical stage a/b heart failure; Risk factors; subclinical cardiovascular diseases; Type 2 diabetes; type 2 diabetes mellitus; China; type 2 diabetes mellitus; subclinical cardiovascular diseases; preclinical stage A/B heart failure; echocardiography
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S385088

Type 2 diabetes mellitus (T2DM) is a common risk factor for cardiovascular disease which increases the risk of heart failure. This study aimed to determine whether clinical characteristics and subclinical cardiovascular disease (CVD) features are correlated with echocardiographic morpho-functional parameters of T2DM patients. Two hundred and fifty-five T2DM patients without a history of coronary heart disease were enrolled in this cross-sectional study. The demographic characteristics, glucose and lipid levels were assessed for each patient. Carotid ultrasonography and peripheral artery examination were performed to measure carotid intima-media thickness (cIMT), carotid plaque, ankle-brachial index (ABI), brachial artery pulse wave velocity (baPWV), and carotid-femoral pulse wave velocity (cfPWV). Furthermore, echocardiography was conducted to evaluate cardiac morphology and systolic and diastolic function. The relationship between clinical characteristics, subclinical cardiovascular diseases, and cardiac morpho-functional parameters was explored with the Pearson and stepwise multivariable linear regression analyses. A total of 255 subjects aged 18-80 years were enrolled in the study. Multiple regression analysis revealed that left ventricular mass index (LVMI) was correlated with age (β=0.463, p = 0.000) and systolic blood pressure (SBP) (β=0.179, p = 0.003). Relative wall thickness (RWT) was related to cfPWV (β=0.006, p = 0.007) and homeostasis model assessment of insulin resistance (HOMA-IR) (β=0.000, p = 0.036). In contrast, left ventricular ejection fraction (LVEF) was inversely related to cIMT (β=-0.925, p = 0.019). The ratio of the peak flow velocity of early diastole to atrial contraction (peak E/A) was correlated with age (β=-0.014, p = 0.000), diastolic blood pressure (DBP) (β=-0.006, p = 0.001) and cfPWV (β=-0.025, p = 0.044). In preclinical stage A/B heart failure adults with T2DM, age, BP, HOMA-IR, cfPWV and cIMT are correlated with cardiac morpho-functional parameters.