Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

• Published in: Journal of autism and developmental disorders Vol. 47; no. 9; pp. 2671 - 2678
• Main Authors: Saad, Khaled, Zahran, Asmaa M., Elsayh, Khalid I., Abdel-Rahman, Ahmed A., Al-Atram, Abdulrahman A., Hussein, Almontaser, El-Gendy, Yasmin G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2017; Springer; Springer Nature B.V
• Subjects: 25-Hydroxyvitamin D; Autism; Autism Spectrum Disorders; Autistic children; Behavior Problems; Behavior Rating Scales; Behavioral Science and Psychology; CD80 antigen; CD86 antigen; Check Lists; Child and School Psychology; Children; College Faculty; Comparative Analysis; Control Groups; Costimulator; Cutting Scores; Cytology; Dendritic cells; Departments; Ethics; Flow cytometry; Genetic Disorders; Identification and classification; Interpersonal Relationship; Medical research; Molecular Biology; Motor Vehicles; Neurosciences; Nonverbal Communication; Original Paper; Patients; Pediatrics; Pervasive Developmental Disorders; Physiological aspects; Psychiatry; Psychological Evaluation; Psychology; Public Health; Serum; T cell receptors; Withdrawal (Psychology); Autism spectrum disorders; Innate immunity; Children; Dendritic cells
• ISSN: 0162-3257; 1573-3432; 1573-3432
• DOI: 10.1007/s10803-017-3190-5

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.