Nucleocytoplasmic Shuttling of p53 Is Essential for MDM2-Mediated Cytoplasmic Degradation but Not Ubiquitination

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Published inMolecular and Cellular Biology Vol. 23; no. 18; pp. 6396 - 6405
Main Authors O'Keefe, Kevin, Li, Huiping, Zhang, Yanping
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.09.2003
Taylor & Francis
Subjects
Active Transport, Cell Nucleus - physiology
Amino Acid Sequence
Amino Acids - chemistry
Cell Growth and Development
Cell Nucleus - metabolism
Cells, Cultured
Conserved Sequence
Cytoplasm - metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Nuclear Localization Signals
Nuclear Proteins
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Ubiquitin - metabolism
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Summary:Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
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Corresponding author. Mailing address: Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009. Phone: (713) 792-8969. Fax: (713) 792-8969. E-mail: ypzhang@mdanderson.org.
ISSN:0270-7306
1098-5549
1098-5549
DOI:10.1128/MCB.23.18.6396-6405.2003