Predictive value of neutrophil-to-apolipoprotein A1 ratio in all-cause and cardiovascular death in elderly non-valvular atrial fibrillation patients

• Published in: Heliyon Vol. 9; no. 1; p. e12918
• Main Authors: Zhang, Xiaoxue, Wei, Meng, Bo, Yakun, Song, Jie, Yu, Yaping, Zhou, Xianhui, Tang, Baopeng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2023; Elsevier
• Subjects: Atrial fibrillation; Cohort study; Mortality; Neutrophil-to-apolipoprotein A1 ratio; Atrial fibrillation; Mortality; Cohort study; Neutrophil-to-apolipoprotein A1 ratio
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e12918

Neutrophil-to-apolipoprotein AI ratio’s (NAR’s) predictive value for the elderly non-valvular atrial fibrillation (NVAF) patients' death has not been fully recognized. We consecutively enrolled 1224 elderly patients with NVAF (≥75 years). With an average follow-up of 733.35 ± 271.39 days, 222 all-cause deaths were identified. Among these, 101 were caused by cardiovascular diseases. Cox regression showed that after correcting for potential confounders, patients in the Q4 group had an increased all-cause (hazard ratio [HR] = 1.90, 95% confidence interval [CI]: 1.20–2.99) and cardiovascular death (HR = 2.59, 95% CI: 1.30–5.15) risk compared to those in the lowest NAR quartile. Kaplan–Meier analysis indicated that all-cause and cardiovascular death were higher in the high NAR than those in the lowest NAR category (log rank, all, P < 0.001). A nonlinear association was observed between death and NAR. NAR may be a promising predictive biomarker for identifying elderly NVAF patients with poor clinical prognoses.