A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target

Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated...

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Bibliographic Details
Published inTechnology in Cancer Research & Treatment Vol. 22; p. 15330338231169873
Main Authors Ma, Li, Wang, Yu, Chen, Peng, Wu, Shixiu
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2023
Sage Publications Ltd
SAGE Publishing
Subjects
beta Catenin - metabolism
Cancer
Carcinoma, Squamous Cell - pathology
Esophageal cancer
Esophageal Neoplasms - pathology
Esophagus
Hedgehog protein
Hedgehog Proteins
Humans
Malignancy
Metastases
Novel Biomarkers, Molecular Diagnostics and Targeted Therapies of Cancer
Radiation therapy
Radiation Tolerance
Radioresistance
Signal Transduction
esophageal cancer
radioresistance
Hedgehog pathway
target therapy
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Summary:Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
These authors contributed equally.
ISSN:1533-0346
1533-0338
DOI:10.1177/15330338231169873