Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia

• Published in: Cell transplantation Vol. 32; p. 9636897231171001
• Main Authors: Var, Susanna R., Strell, Phoebe, Johnson, Sether T., Roman, Alex, Vasilakos, Zoey, Low, Walter C.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2023; Sage Publications Ltd; SAGE Publishing
• Subjects: Alzheimer's disease; Central Nervous System; Dietary Supplements; Humans; Life span; Microglia; Microglia - pathology; Nervous System Diseases - pathology; Nervous System Diseases - therapy; Neurodegenerative diseases; Neurological diseases; Neuroprotection; Parkinson's disease; Review; Transplantation; Transplants; neurodegenerative disease; blastocyst complementation; neuroinflammation; transplantation; CNS injury; exogenic; aging; microglia; Alzheimer’s

Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease,...