Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia

Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease,...

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Published inCell transplantation Vol. 32; p. 9636897231171001
Main Authors Var, Susanna R., Strell, Phoebe, Johnson, Sether T., Roman, Alex, Vasilakos, Zoey, Low, Walter C.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2023
Sage Publications Ltd
SAGE Publishing
Subjects
Alzheimer's disease
Central Nervous System
Dietary Supplements
Humans
Life span
Microglia
Microglia - pathology
Nervous System Diseases - pathology
Nervous System Diseases - therapy
Neurodegenerative diseases
Neurological diseases
Neuroprotection
Parkinson's disease
Review
Transplantation
Transplants
neurodegenerative disease
blastocyst complementation
neuroinflammation
transplantation
CNS injury
exogenic
aging
microglia
Alzheimer’s
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Summary:Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, and CNS-related injuries, and can accelerate or worsen the condition. Transplantation studies designed to replace and supplement dysfunctional microglia with healthy microglia offer a promising strategy for addressing microglia-mediated neuroinflammation and pathologies. This review will cover microglial involvement in neurological diseases and disorders and CNS-related injuries, current microglial transplantation strategies, and different approaches and considerations for generating exogenic microglia.
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ISSN:0963-6897
1555-3892
1555-3892
DOI:10.1177/09636897231171001