Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial

• Published in: Vaccine Vol. 29; no. 44; pp. 7595 - 7598
• Main Authors: van Gils, Elske J.M, Veenhoven, Reinier H, Rodenburg, Gerwin D, Hak, Eelko, Sanders, Elisabeth A.M
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 13.10.2011; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Antibiotics; Applied microbiology; Bacteriology; Biological and medical sciences; Carriage; Carrier State - epidemiology; Carrier State - microbiology; Child, Preschool; children; Children & youth; Colonization; Female; Fundamental and applied biological sciences. Psychology; Haemophilus influenzae; Haemophilus influenzae - isolation & purification; Heptavalent Pneumococcal Conjugate Vaccine; Humans; Immunization; Infant; Infants; Male; Microbiology; Miscellaneous; Moraxella (Branhamella) catarrhalis - isolation & purification; Moraxella catarrhalis; Nasopharynx - microbiology; Otitis media; pathogens; Pneumococcal conjugate vaccine; Pneumococcal Vaccines - immunology; Pneumonia; randomized clinical trials; Replacement; serotypes; Streptococcus pneumoniae; Streptococcus pneumoniae - isolation & purification; Studies; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Pneumococcal conjugate vaccine; Otitis media; Moraxella catarrhalis; Replacement; Infants; Colonization; Haemophilus influenzae; Carriage; Human; Pseudomonadales; Middle ear disease; Infant; Vaccine; Streptococcus pneumoniae; Pasteurellaceae; Streptococcaceae; Bacteria; Micrococcales; ENT disease; Moraxellaceae
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.08.049

Abstract Seven-valent CRM197-conjugated pneumococcal conjugate vaccine (PCV7CRM197 ) reduces both vaccine serotype nasopharyngeal colonization and vaccine serotype acute otitis media by 50–60%. However, overall pneumococcal carriage and impact on otitis media are partly offset by concomitant increase of nonvaccine serotypes. We investigated in a randomized controlled trial the impact of 2-doses and 2 + 1-doses of PCV7CRM197 on carriage of Streptococcus pneumoniae and of other nasopharyngeal commensals and well-known otitis media pathogens, Haemophilus influenzae and Moraxella catarrhalis, in children. Nasopharyngeal swabs were collected at the age of 6 weeks and at 6, 12, 18 and 24 months. We observed high carriage rates up to 68% for S. pneumoniae , 71% for H. influenzae and 68% for M. catarrhalis at the age of 18 months. Reduced doseCRM197 schedules induced a slight reduction in overall pneumococcal carriage but no increases in the presence of H. influenzae and M. catarrhalis.