Comparative Study of Collagen versus Synthetic-Based Meniscal Scaffolds in Treating Meniscal Deficiency in Young Active Population

• Published in: Cartilage Vol. 7; no. 1; pp. 29 - 38
• Main Authors: Bulgheroni, Erica, Grassi, Alberto, Campagnolo, Monica, Bulgheroni, Paolo, Mudhigere, Abhishek, Gobbi, Alberto
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2016
• Subjects: knee; scaffolds; meniscal injury; meniscus; polarized light microscopy
• ISSN: 1947-6035; 1947-6043
• DOI: 10.1177/1947603515600219

Purpose: The aim of this study was to compare the effectiveness of 2 different meniscal scaffolds in treating patients with irreparable partial medial meniscal tear and patients complaining of pain in the medial compartment of the knee due to a previous partial medial meniscectomy. Based on previous studies, we hypothesized that both the scaffolds are effective in improving clinical outcomes in these patient populations. Material and Methods: Twenty-eight patients underwent collagen-based medial meniscus implantation (CMI-Menaflex) and 25 with a second-generation scaffold (Actifit). All patients were assessed with Lysholm, Tegner scale, and MRI evaluation—preoperatively, at 6 months, at 12 moths, and followed-up for a minimum of 2 years. Second look arthroscopy and concomitant biopsy were performed in 7 and 12 patients of CMI and Actifit groups, respectively. Results: The CMI group at final follow-up showed improvement in Lysholm score from 58.4 ± 17.3 to 94.5 ± 6.0, while the Actifit group showed improvement from 67.0 ± 15.7 to 90.3 ± 13.1; the improvement was statistically significant in both the groups but intergroup difference was not statistically significant (P = 0.1061). Tegner Activity Scale score improved in both the groups, but intergroup difference was not statistically significant (P = 0.5918). MRI evaluation showed in situ scaffold and no progression of degenerative arthritis in both the groups at final follow-up. Histological evaluation showed more fibrous tissue with blood vessels in the CMI group and the Actift group showed avascular cartilaginous features. Conclusion: Both the scaffolds are effective in improving patients’ symptoms and joint function at short-term follow-up.