Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse

Hyaline glomerulopathy is a type of glomerular lesion that occurs in aging mice. Spontaneous hyaline glomerulopathy is rare in young mice. Here, we report spontaneous hyaline glomerulopathy in a young adult (15-week-old) ICR mouse. Necropsy revealed discoloration and roughness of the kidney surface....

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Published inJournal of Toxicologic Pathology Vol. 33; no. 4; pp. 303 - 307
Main Authors Nishina, Hironobu, Kashimura, Akane, Sakairi, Tetsuya, Nishikawa, Satomi, Mizukawa, Mao, Sato, Hiroko
Format Journal Article
LanguageEnglish
Published Tokyo JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY 01.01.2020
Japan Science and Technology Agency
Japanese Society of Toxicologic Pathology
Subjects
Aging
Amorphous materials
Capillaries
Case Report
Cell proliferation
Deposits
Discoloration
Electron microscopy
Epithelial cells
glomerulopathy
hyaline glomerulopathy
ICR mouse
immunoglobulin
Immunoglobulin G
Immunoglobulin M
Kidneys
Lesions
Leukocytes (eosinophilic)
Mesangial cells
Necropsy
spontaneous lesion
Stains
Thickening
Young adults
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Summary:Hyaline glomerulopathy is a type of glomerular lesion that occurs in aging mice. Spontaneous hyaline glomerulopathy is rare in young mice. Here, we report spontaneous hyaline glomerulopathy in a young adult (15-week-old) ICR mouse. Necropsy revealed discoloration and roughness of the kidney surface. Microscopically, diffuse glomerular lesions were prominent. Amorphous, eosinophilic materials were deposited globally in the glomeruli. The mesangial region was expanded; however, the mesangial cells showed no proliferation. Thickening of the Bowman’s capsule with proliferation of parietal epithelial cells was observed. Glomerular deposits were strongly positive for anti-IgM, anti-IgG, and periodic acid-Schiff stain and were stained red by Masson’s trichrome stain. The deposits were negative for anti C3 and stained negatively with Congo red stain. Periodic acid methenamine silver and electron microscopy revealed glomerular deposits limited to intraglomerular capillaries. Based on the histological features, we diagnosed this lesion as hyaline glomerulopathy. This case could improve our understanding of spontaneous lesions in toxicological and pharmacological studies.
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ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2020-0027