E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas

Cancer metastasis follows a sequential series of events, and many of the critical steps are distinctly similar to EMT-like transformations that occur during normal embryonic development. A current area of focus is the similarities between how cancer cells interact with the ectopic parenchyma after m...

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Bibliographic Details
Published inClinical & experimental metastasis Vol. 25; no. 6; pp. 621 - 628
Main Authors Wells, Alan, Yates, Clayton, Shepard, Christopher R.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 2008
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cadherins - metabolism
Cancer Research
Cell Transformation, Neoplastic
Epithelial Cells - pathology
Hematology
Humans
Mesoderm - pathology
Neoplasm Invasiveness
Neoplasm Metastasis - pathology
Neoplasms - pathology
Oncology
Research Paper
Signal Transduction - physiology
Surgical Oncology
Cancer dissemination
Growth factor receptors
Differentiation
Tumor dormancy
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Summary:Cancer metastasis follows a sequential series of events, and many of the critical steps are distinctly similar to EMT-like transformations that occur during normal embryonic development. A current area of focus is the similarities between how cancer cells interact with the ectopic parenchyma after metastatic spread, and secondary developmental MET events that occur in epithelial tissues that have re-assembled within the embryo from mesenchymal cells. Accumulating evidence suggests a critical role for these secondary events, termed mesenchymal-epithelial transitions (MET) in development and mesenchymal-epithelial reverting transitions (MErT) in cancer. In this situation, metastatic seed cancer cells may inertly become part of the ectopic tissue and therefore surmount the metastatic inefficiencies to which most disseminated cancer cells succumb. Just as a critical EMT event is the downregulation or silencing of E-cadherin, we discuss the role of E-cadherin in cancer-associated MErT at distant metastatic sites and speculate on the implications for the fate of micrometastases that undergo a transition to being E-cadherin positive.
ISSN:0262-0898
1573-7276
DOI:10.1007/s10585-008-9167-1