Delayed onset of severe neonatal toxoplasmosis

• Published in: Journal of perinatology Vol. 30; no. 3; pp. 231 - 232
• Main Authors: Al-Hamod, D, Vauloup, C, Goulet, M, Zupan-Simunek, V, Castel, C, Boileau, P
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2010; Nature Publishing Group
• Subjects: 631/443/494; 692/420/256/1980; 692/699/255/1715; 692/700/1720; Adolescent; Antiprotozoal Agents - therapeutic use; Care and treatment; Case reports; Case studies; Diagnosis; Female; Health aspects; Heart Arrest - etiology; Humans; Hypertension; Infant, Newborn; Infants (Newborn); Male; Medical examination; Medicine; Medicine & Public Health; Mimicry; Neonates; Newborn babies; Patient outcomes; Pediatric Surgery; Pediatrics; perinatal-neonatal-case-presentation; Pregnancy; Pyrimethamine - therapeutic use; Respiratory distress syndrome; Risk factors; Septic shock; Shock, Septic - diagnosis; Shock, Septic - drug therapy; Shock, Septic - parasitology; Sulfadiazine - therapeutic use; Thrombocytopenia; Toxoplasma gondii; Toxoplasmosis; Toxoplasmosis, Congenital - complications; Toxoplasmosis, Congenital - diagnosis; Toxoplasmosis, Congenital - drug therapy; France; neonatal; septic shock; persistent pulmonary hypertension; toxoplasmosis; thrombocytopenia
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2009.184

We report a case of severe neonatal infection on day 6 of life due to Toxoplasma gondii mimicking septic shock syndrome associated with multiple organ failure such as acute respiratory distress syndrome with persistent pulmonary hypertension, neurological distress, thrombocytopenia with disseminated intravascular coagulopathy and transaminitis. Clinicians facing an unexplained life-threatening condition in the first week of life should take into consideration the possibility of neonatal toxoplasmosis.