The fungal microbiota of de-novo paediatric inflammatory bowel disease

• Published in: Microbes and infection Vol. 17; no. 4; pp. 304 - 310
• Main Authors: Mukhopadhya, I., Hansen, R., Meharg, C., Thomson, J.M., Russell, R.K., Berry, S.H., El-Omar, E.M., Hold, G.L.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.04.2015; Elsevier
• Subjects: Adult; Child; Child, Preschool; Fungal microbiota; Fungi - classification; Fungi - genetics; Fungi - pathogenicity; Gut microbiota; Humans; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - microbiology; Intestinal Mucosa - microbiology; Microbiota - genetics; Paediatric inflammatory bowel disease; Short Communication; Gut microbiota; Paediatric inflammatory bowel disease; Fungal microbiota
• ISSN: 1286-4579; 1769-714X; 1769-714X
• DOI: 10.1016/j.micinf.2014.12.001

Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients.