Mutagenicity Tests with a Permeable Mutant of Yeast on Carcinogens Showing False-Negative in Salmonella Assay
The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3, 4-benzpyrene and 2-acetylaminofluorene has been detected with the permeable mutant of yeast, Saccharomyces cerevisiae C658-K42. The original strain C658, however, showed a positive response only to N-nitrosodimeth...
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| Published in | Chemical & pharmaceutical bulletin Vol. 37; no. 2; pp. 407 - 409 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
01.02.1989
Maruzen Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-2363 1347-5223 |
| DOI | 10.1248/cpb.37.407 |
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| Abstract | The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3, 4-benzpyrene and 2-acetylaminofluorene has been detected with the permeable mutant of yeast, Saccharomyces cerevisiae C658-K42. The original strain C658, however, showed a positive response only to N-nitrosodimethylamine with S9 mix. The permeable mutant C658-K42 was employed for mutagenicity tests on 12 carcinogens which had been reported to be non-mutagenic in Salmonella/microsome tests. It was found that phenobarbital, thiourea, 1, 2-dimethylhydrazine and 4-aminoantipyrine were mutagenic in the presence of S9 mix, Benzene, o-toluidine and thioacetamide were weakly mutagenic. Negative results were obtained for diethylstilbestrol, safrole, acetamide, urethane and ethionine at the concentrations used. Caprolactam did not show any mutagenic effect on C658-K42 at concentrations up to 20 mg/ml. Sodium azide, which is unlikely to be carcinogenic but is strongly mutagenic in the Ames test, showed a very weak mutagenic effect on C658-K42. |
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| AbstractList | The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3, 4-benzpyrene and 2-acetylaminofluorene has been detected with the permeable mutant of yeast, Saccharomyces cerevisiae C658-K42. The original strain C658, however, showed a positive response only to N-nitrosodimethylamine with S9 mix. The permeable mutant C658-K42 was employed for mutagenicity tests on 12 carcinogens which had been reported to be non-mutagenic in Salmonella/microsome tests. It was found that phenobarbital, thiourea, 1, 2-dimethylhydrazine and 4-aminoantipyrine were mutagenic in the presence of S9 mix, Benzene, o-toluidine and thioacetamide were weakly mutagenic. Negative results were obtained for diethylstilbestrol, safrole, acetamide, urethane and ethionine at the concentrations used. Caprolactam did not show any mutagenic effect on C658-K42 at concentrations up to 20 mg/ml. Sodium azide, which is unlikely to be carcinogenic but is strongly mutagenic in the Ames test, showed a very weak mutagenic effect on C658-K42. The mutagenicity (Trp super(+) reversion) of procarcinogens such as N-nitrosodimethylamine, 3,4-benzpyrene and 2-acetylaminofluorene has been detected with the permeable mutant of yeast, Saccharomyces cerevisiae) C658-K42. The original strain C658 showed a positive response only to N-nitrosodimethylamine with S9 mix. The permeable mutant C658-K42 was employed for mutagenicity tests on 12 carcinogens which had been reported to be non-mutagenic in Salmonella /microsome tests. Phenobarbital, thiourea, 1,2-dimethylhydrazine and 4-aminoantipyrine were mutagenic in the presence of S9 mix. Benzene, o-toluidine and thioacetamide were weakly mutagenic. Negative results were obtained for diethylstilbestrol, safrole, acetamide, urethane and ethionine. Caprolactam did not show any mutagenic effect on C658-K42 at concentrations up to 20 mg/ml. Sodium azide, unlikely to be carcinogenic but strongly mutagenic in the Ames test, showed a weak mutagenic effect on C658-K42. The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3,4-benzpyrene and 2-acetylaminofluorene has been detected with the permeable mutant of yeast, Saccharomyces cerevisiae C658-K42. The original strain C658, however, showed a positive response only to N-nitrosodimethylamine with S9 mix. The permeable mutant C658-K42 was employed for mutagenicity tests on 12 carcinogens which had been reported to be non-mutagenic in Salmonella/microsome tests. It was found that phenobarbital, thiourea, 1,2-dimethylhydrazine and 4-aminoantipyrine were mutagenic in the presence of S9 mix. Benzene, o-toluidine and thioacetamide were weakly mutagenic. Negative results were obtained for diethylstilbestrol, safrole, acetamide, urethane and ethionine at the concentrations used. Caprolactam did not show any mutagenic effect on C658-K42 at concentrations up to 20 mg/ml. Sodium azide, which is unlikely to be carcinogenic but is strongly mutagenic in the Ames test, showed a very weak mutagenic effect on C658-K42.The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3,4-benzpyrene and 2-acetylaminofluorene has been detected with the permeable mutant of yeast, Saccharomyces cerevisiae C658-K42. The original strain C658, however, showed a positive response only to N-nitrosodimethylamine with S9 mix. The permeable mutant C658-K42 was employed for mutagenicity tests on 12 carcinogens which had been reported to be non-mutagenic in Salmonella/microsome tests. It was found that phenobarbital, thiourea, 1,2-dimethylhydrazine and 4-aminoantipyrine were mutagenic in the presence of S9 mix. Benzene, o-toluidine and thioacetamide were weakly mutagenic. Negative results were obtained for diethylstilbestrol, safrole, acetamide, urethane and ethionine at the concentrations used. Caprolactam did not show any mutagenic effect on C658-K42 at concentrations up to 20 mg/ml. Sodium azide, which is unlikely to be carcinogenic but is strongly mutagenic in the Ames test, showed a very weak mutagenic effect on C658-K42. |
| Author | MASUZAWA, Toshiyuki MORITA, Tamotsu IWAMOTO, Yoshihisa YANAGIHARA, Yasutake SHIMIZU, Tadayori |
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| References | 3) a) S.J. Rinkus and M.S. Legator, Cancer Res., 39, 3289 (1979 5) J.M. Parry, "Progress in Mutation Research, Vol. 5, Evaluation of Short-Term Tests for Carcinogens," ed. by J. Ashby, F.J. de Serres, M. Draper, M. Ishidate Jr., B.H. Margolin, B.E. Matter and M.D. Shelby, Elsevier Science Publishers, Amsterdam, Oxford, New York, 1985, pp. 25-46. 8) J. McCann and B.N. Ames, Proc. Natl. Acad. Sci. U.S.A., 73, 950 (1976). 14) E. Moustacchi, Arch. Toxicol., 46, 99 (1980). 13) P.F. Swan, A.E. Pegg, A. Hawks, E. Farber and P.H. Magee, Biochem. J., 123, 175 (1971). 11) V.F. Simmon, J. Natl. Cancer Inst., 62, 901 (1979). b) S.J. Rinkus and M.S. Legator, "Chemical Mutagens: Principles and Methods for Their Detection," Vol. 6, ed. by F.J. de Serres and A. Hollaender, Plenum Press, New York, 1980, pp. 365-473. 9) P. Borchert, J.A. Miller, E.C. Miller and T.K. Shires, Cancer Res., 33, 590 (1973). 7) T. Morita and I. Mifuchi, Chem. Pharm. Bull., 32, 1624 (1984). 1) T. Morita and Y. Yanagihara, Chem. Pharm. Bull., 33, 1576 (1985). 12) K.H. Shull, J. McConomy, M. Vogt, A. Castillo and E. Farber, J. Biol. Chem., 241, 5060 (1966). 4) J. McCann, E. Choi, E. Yamasaki and B.N. Ames, Proc. Natl. Acad. Sci. U.S.A., 72, 5135 (1975). 10) J. McCann, N.E. Spingarn, J. Kobori and B.N. Ames, Proc. Natl. Acad. Sci. U.S.A., 72, 979 (1975). 6) D.F. Callen and R.M. Philpot, Mutat. Res., 45, 309 (1977). 2) O. Kappeli, Microbiol. Rev., 50, 244 (1986). |
| References_xml | – reference: 5) J.M. Parry, "Progress in Mutation Research, Vol. 5, Evaluation of Short-Term Tests for Carcinogens," ed. by J. Ashby, F.J. de Serres, M. Draper, M. Ishidate Jr., B.H. Margolin, B.E. Matter and M.D. Shelby, Elsevier Science Publishers, Amsterdam, Oxford, New York, 1985, pp. 25-46. – reference: 4) J. McCann, E. Choi, E. Yamasaki and B.N. Ames, Proc. Natl. Acad. Sci. U.S.A., 72, 5135 (1975). – reference: 8) J. McCann and B.N. Ames, Proc. Natl. Acad. Sci. U.S.A., 73, 950 (1976). – reference: 13) P.F. Swan, A.E. Pegg, A. Hawks, E. Farber and P.H. Magee, Biochem. J., 123, 175 (1971). – reference: b) S.J. Rinkus and M.S. Legator, "Chemical Mutagens: Principles and Methods for Their Detection," Vol. 6, ed. by F.J. de Serres and A. Hollaender, Plenum Press, New York, 1980, pp. 365-473. – reference: 11) V.F. Simmon, J. Natl. Cancer Inst., 62, 901 (1979). – reference: 1) T. Morita and Y. Yanagihara, Chem. Pharm. Bull., 33, 1576 (1985). – reference: 14) E. Moustacchi, Arch. Toxicol., 46, 99 (1980). – reference: 2) O. Kappeli, Microbiol. Rev., 50, 244 (1986). – reference: 7) T. Morita and I. Mifuchi, Chem. Pharm. Bull., 32, 1624 (1984). – reference: 10) J. McCann, N.E. Spingarn, J. Kobori and B.N. Ames, Proc. Natl. Acad. Sci. U.S.A., 72, 979 (1975). – reference: 9) P. Borchert, J.A. Miller, E.C. Miller and T.K. Shires, Cancer Res., 33, 590 (1973). – reference: 3) a) S.J. Rinkus and M.S. Legator, Cancer Res., 39, 3289 (1979) – reference: 12) K.H. Shull, J. McConomy, M. Vogt, A. Castillo and E. Farber, J. Biol. Chem., 241, 5060 (1966). – reference: 6) D.F. Callen and R.M. Philpot, Mutat. Res., 45, 309 (1977). |
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| Snippet | The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3, 4-benzpyrene and 2-acetylaminofluorene has been detected with the... The mutagenicity (Trp+ reversion) of procarcinogens such as N-nitrosodimethylamine, 3,4-benzpyrene and 2-acetylaminofluorene has been detected with the... The mutagenicity (Trp super(+) reversion) of procarcinogens such as N-nitrosodimethylamine, 3,4-benzpyrene and 2-acetylaminofluorene has been detected with the... |
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| SubjectTerms | Animals Biological and medical sciences carcinogen Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity cell permeability Chemical agents false-negative In Vitro Techniques Medical sciences mutagenicity test Mutagenicity Tests Mutagens permeable mutant Rats Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Salmonella typhimurium - genetics Tumors |
| Title | Mutagenicity Tests with a Permeable Mutant of Yeast on Carcinogens Showing False-Negative in Salmonella Assay |
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