Thyroid Diseases after Treatment of Hodgkin's Disease

• Published in: The New England journal of medicine Vol. 325; no. 9; pp. 599 - 605
• Main Authors: Hancock, Steven L, Cox, Richard S, McDougall, I. Ross
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 29.08.1991
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Child; Child, Preschool; Combined Modality Therapy; Disease; Female; Goiter, Nodular - etiology; Graves Disease - etiology; Hemopathies; Hodgkin Disease - radiotherapy; Hodgkin Disease - therapy; Humans; Hyperthyroidism - etiology; Hypothyroidism - etiology; Male; Medical disorders; Medical research; Medical sciences; Middle Aged; Neoplasms, Radiation-Induced - etiology; Radiation; Radiotherapy - adverse effects; Radiotherapy Dosage; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Risk Factors; Therapy; Thyroid cancer; Thyroid Diseases - etiology; Thyroid Gland - radiation effects; Thyroid Neoplasms - etiology; Thyroiditis - etiology; Thyrotoxicosis - etiology; Time Factors; Endocrinopathy; Human; Treatment; Lymphoproliferative syndrome; Thyroid diseases; Complication; Hodgkin disease; Malignant hemopathy; Radiotherapy
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199108293250902

A VARIETY of thyroid diseases have been found in patients treated for Hodgkin's disease; among them, hypothyroidism is the most common. Hypothyroidism was first recognized as a complication of external irradiation of the neck for Graves' disease in 1929 and was first reported in 1965 in patients who were euthyroid before neck irradiation. 1 2 3 4 A high incidence of hypothyroidism was reported from our institution in 1971 among patients treated for lymphoma, a finding confirmed by other investigators. 5 6 7 8 9 10 11 12 13 Iodinated radiographic contrast agents may or may not contribute to the risk of hypothyroidism, and the effect of chemotherapy has not been determined. Graves' . . .