Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma

• Published in: British journal of cancer Vol. 87; no. 10; pp. 1140 - 1144
• Main Authors: SUZUOKI, M, MIYAMOTO, M, KONDO, S, KATOH, H, KATO, K, HIRAOKA, K, OSHIKIRI, T, NAKAKUBO, Y, FUKUNAGA, A, SHICHINOHE, T, SHINOHARA, T, ITOH, T
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 04.11.2002
• Subjects: Adenocarcinoma - chemistry; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adult; Aged; Biological and medical sciences; Cancer research; Caveolin 1; Caveolins - analysis; Chronic Disease; Female; Gastroenterology. Liver. Pancreas. Abdomen; Growth factors; Hospitals; Humans; Immunohistochemistry; Kinases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical prognosis; Medical research; Medical sciences; Metastasis; Middle Aged; Molecular and Cellular Pathology; Oncology; Pancreatic cancer; Pancreatic Neoplasms - chemistry; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Pancreatitis - metabolism; Pathology; Prognosis; Prostate cancer; Signal transduction; Survival Rate; Tumors; Japan; Adenocarcinoma; Human; caveolin-1; Prognosis; pancreatic carcinoma; Gene overexpression; Digestive diseases; Genetics; Malignant tumor; immunohistochemistry; Pancreas; Pancreatic disease
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6600619

Caveolin-1 is a major component of caveolae and plays a regulatory role in several signalling pathways. Caveolin-1 was recently identified as a metastasis-related gene in prostate cancer. The clinical effects of caveolin-1 expression in pancreatic carcinoma, however, remain unknown. In this study, we have investigated the relationship between caveolin-1 expression and the clinicopathologic variables and clinical outcome in 79 patients with pancreatic adenocarcinoma undergoing surgical resection. Caveolin-1 expression was determined by immunohistochemistry, using a polyclonal anti-caveolin-1 antibody. Patients were divided into two groups based on the extent of caveolin-1 expression: a negative expression group (immunoreactivity in less than 50% of cells) and a positive expression group. Positive caveolin-1 immunostaining was detected in 32 cases (40.5% of total), while non-neoplastic ductal epithelium showed little or no staining. Positive caveolin-1 expression was correlated with tumour diameter (P=0.0079), histopathologic grade (P=0.0272) and poor prognosis (P=0.0008). Upon multivariate analysis with Cox's proportional hazards model, positive caveolin-1 expression was shown to be an independent negative predictor for survival (P=0.0358). These results suggest that caveolin-1 overexpression is associated with tumour progression, thereby indicating a poor prognosis for certain patients undergoing surgical resection for pancreatic carcinoma.