The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens

• Published in: Technology in Cancer Research & Treatment Vol. 22; p. 15330338231206003
• Main Authors: Tavakoli Pirzaman, Ali, Ebrahimzadeh Pirshahid, Manijeh, Babajani, Bahareh, Rahmati, Amirhossein, Niknezhad, Shokat, Hosseinzadeh, Rezvan, Taheri, Mehdi, Ebrahimi-Zadeh, Faezeh, Doostmohamadian, Shahrbanoo, Kazemi, Sohrab
• Format: Book Review Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2023; Sage Publications Ltd; SAGE Publishing
• Subjects: Apoptosis; Cancer therapies; Carcinoma, Hepatocellular; Cell death; Cell Line, Tumor; Cell Proliferation; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Cyclohexane; Drug Resistance, Neoplasm; Gastric cancer; Gene Expression Regulation, Neoplastic; Glypicans - metabolism; Glypicans - pharmacology; Glypicans - therapeutic use; Heparan sulfate proteoglycans; Humans; Immunosuppressive agents; Liver Neoplasms - genetics; Lung cancer; Male; MicroRNAs; MicroRNAs - metabolism; miRNA; Neuralgia; Non-coding RNA; Nucleotides; Oxaliplatin; Oxaliplatin - pharmacology; Prostate cancer; PTEN protein; Review; Stomach Neoplasms - pathology; Tumor Microenvironment; Up-regulation; Wnt protein; β-Catenin; microRNAs; gastrointestinal; oxaliplatin; chemoresistance; cancer
• ISSN: 1533-0346; 1533-0338; 1533-0338
• DOI: 10.1177/15330338231206003

Oxaliplatin (cyclohexane-1,2-diamine; oxalate; platinum [2+]) is a third-generation chemotherapeutic drug with anticancer effects. Oxaliplatin has a role in the treatment of several cancers. It is one of the few drugs which can eliminate the neoplastic cells of colorectal cancer. Also, it has an influential role in breast cancer, lung cancer, bladder cancer, prostate cancer, and gastric cancer. Although oxaliplatin has many beneficial effects in cancer treatment, resistance to this drug is in the way to cure neoplastic cells and reduce treatment efficacy. microRNAs are a subtype of small noncoding RNAs with ∼22 nucleotides that exist among species. They have diverse roles in physiological processes, including cellular proliferation and cell death. Moreover, miRNAs have essential roles in resistance to cancer treatment and can strengthen sensitivity to chemotherapeutic drugs and regimens. In colorectal cancer, the co-treatment of oxaliplatin with anti-miR-19a can partially reverse the oxaliplatin resistance through the upregulation of phosphatase and tensin homolog (PTEN). Moreover, by preventing the spread of gastric cancer cells and downregulating glypican-3 (GPC3), MiR-4510 may modify immunosuppressive signals in the tumor microenvironment. Treatment with oxaliplatin may develop into a specialized therapeutic drug for patients with miR-4510 inhibition and glypican-3-expressing gastric cancer. Eventually, miR-122 upregulation or Wnt/β-catenin signaling suppression boosted the death of HCC cells and made them more sensitive to oxaliplatin. Herein, we have reviewed the role of microRNAs in regulating cancer cells’ response to oxaliplatin, with particular attention to gastrointestinal cancers. We also discussed the role of these noncoding RNAs in the pathophysiology of oxaliplatin-induced neuropathic pain.