Improving biocompatibility for next generation of metallic implants

The increasing need for joint replacement surgeries, musculoskeletal repairs, and orthodontics worldwide prompts emerging technologies to evolve with healthcare's changing landscape. Metallic orthopaedic materials have a shared application history with the aerospace industry, making them only p...

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Bibliographic Details
Published inProgress in materials science Vol. 133; p. 101053
Main Authors Bandyopadhyay, Amit, Mitra, Indranath, Goodman, Stuart B., Kumar, Mukesh, Bose, Susmita
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2023
Subjects
3D printing
Additive manufacturing
Alloys
Biocompatibility
Implants
Metals
Biocompatibility
Additive manufacturing
Metals
3D printing
Implants
Alloys
3D Printing
additive manufacturing
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Summary:The increasing need for joint replacement surgeries, musculoskeletal repairs, and orthodontics worldwide prompts emerging technologies to evolve with healthcare's changing landscape. Metallic orthopaedic materials have a shared application history with the aerospace industry, making them only partly efficient in the biomedical domain. However, suitability of metallic materials in bone tissue replacements and regenerative therapies remains unchallenged due to their superior mechanical properties, eventhough they are not perfectly biocompatible. Therefore, exploring ways to improve biocompatibility is the most critical step toward designing the next generation of metallic biomaterials. This review discusses methods of improving biocompatibility of metals used in biomedical devices using surface modification, bulk modification, and incorporation of biologics. Our investigation spans multiple length scales, from bulk metals to the effect of microporosities, surface nanoarchitecture, and biomolecules such as DNA incorporation for enhanced biological response in metallic materials. We examine recent technologies such as 3D printing in alloy design and storing surface charge on nanoarchitecture surfaces, metal-on-metal, and ceramic-on-metal coatings to present a coherent and comprehensive understanding of the subject. Finally, we consider the advantages and challenges of metallic biomaterials and identify future directions.
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Stuart B Goodman
School of Mechanical and Materials Engineering, Affiliate Professor, Elson S. Floyd College of Medicine, Washington State University, Pullman, WA 99164-2920, Fellow SME, WSAS, NAI, AAAS, ASM International, AIMBE, and ACerS, Phone: (509) 336-9187 (cell), https://mme.wsu.edu/amit-bandyopadhyay/, Google Scholar: https://scholar.google.com/citations?user=CWnufe8AAAAJ&hl=en
School of Mechanical and Materials Engineering, Affiliate faculty, Department of Chemistry, Affiliate faculty, Elson Floyd College of Medicine, Washington State University, Pullman, WA 99164-2920, Phone: (509) 335-7461; https://mme.wsu.edu/susmita-bose/, Google scholar: https://scholar.google.com/citations?user=vO3tQrkAAAAJ&hl=en
Susmita Bose
Mukesh Kumar
Information about the authors
Robert L. and Mary Ellenburg Professor of Surgery, Professor, Department of Orthopaedic Surgery and (by courtesy) Bioengineering, Stanford University Medical Center Outpatient Center, 450 Broadway St., M/C 6342; Redwood City, CA 94063, USA. Phone: 650-721-7662, Google scholar: https://scholar.google.com/citations?user=k-0L5NAAAAAJ&hl=en&oi=sra
Indranath Mitra
Lead author: Amit Bandyopadhyay
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, Google Scholar: https://scholar.google.com/citations?user=4ANCbeAAAAAJ&hl=en&oi=ao
d. | m. 3179898461, LINCOTEK MEDICAL|lincotekmedical.com, 3110 Stage Post Drive | 38133 Bartlett, Tennessee | United States, t. +1+901-590-4240
ISSN:0079-6425
1873-2208
DOI:10.1016/j.pmatsci.2022.101053