Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine

WATANABA, H., KAWAI, K, and CHIBA, S. Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine. Tohoku J. exp. Med., 1982, 136 (1), 75-78 The effects of acetylcholine on the frequency-force relationship in isolated dog atria were investigated in a frequency range of 2-3.5Hz. Th...

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Published inThe Tohoku Journal of Experimental Medicine Vol. 136; no. 1; pp. 75 - 78
Main Authors WATANABE, HIDEHIKO, KAWAI, KIMIKO, CHIBA, SHIGETOSHI
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 1982
Subjects
acetylcholine
Acetylcholine - pharmacology
Animals
Dogs
Dose-Response Relationship, Drug
Electric Stimulation
frequency-force relationship
Heart Atria
In Vitro Techniques
isolated dog atria
Myocardial Contraction - drug effects
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Summary:WATANABA, H., KAWAI, K, and CHIBA, S. Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine. Tohoku J. exp. Med., 1982, 136 (1), 75-78 The effects of acetylcholine on the frequency-force relationship in isolated dog atria were investigated in a frequency range of 2-3.5Hz. The atria were suspended in a bath and perfused with arterial blood from a carotid artery of a heparinized donor dog. The frequency-force relationship was uniformly and dose-dependently suppressed by infusion of acetylcholin in 3 different doses at the frequency range of 2-3.5Hz, and acetylcholine did not induce a negative staircase.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.136.75