Drug targets for lymphatic filariasis: A bioinformatics approach

• Published in: Journal of vector borne diseases Vol. 50; no. 3; pp. 155 - 162
• Main Authors: Sharma, OmPrakash, Vadlamudi, Yellamandaya, Kota, ArunGupta, Sinha, VikrantKumar, Kumar, MuthuvelSuresh
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.09.2013; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Animals; Bioinformatics; Bioinformatics; filariasis drug targets; filariasis elimination programmes; lymphatic filariasis; proteomics and genomics; Brugia malayi - drug effects; Brugia malayi - genetics; Care and treatment; Computational Biology; Data bases; Drug Discovery; Elephantiasis, Filarial - drug therapy; Elephantiasis, Filarial - parasitology; Filariasis; Filaricides - pharmacology; Genome, Helminth - genetics; Genomes; Helminth Proteins - drug effects; Helminth Proteins - genetics; Humans; Lymphatic system; Medical research; Medicine, Experimental; Morbidity; Mortality; Nematodes; Patient education; Public health; Studies; Tropical diseases; Worms; Wuchereria bancrofti - drug effects; Wuchereria bancrofti - genetics; India
• ISSN: 0972-9062; 0972-9062
• DOI: 10.4103/0972-9062.120916

This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and their achievements to eradicate this most debilitating disease from the earth. Since, bioinformatics is a rapidly growing field of biological study, and it has an increasingly significant role in various fields of biology. We have reviewed its leading involvement in the filarial research using different approaches of bioinformatics and have summarized available existing drugs and their targets to re-examine and to keep away from the resisting conditions. Moreover, some of the novel drug targets have been assembled for further study to design fresh and better pharmacological therapeutics. Various bioinformatics-based web resources, and databases have been discussed, which may enrich the filarial research.