Immunologic and Virologic Status after 14 to 18 Years of Infection with an Attenuated Strain of HIV-1 — A Report from the Sydney Blood Bank Cohort

• Published in: The New England journal of medicine Vol. 340; no. 22; pp. 1715 - 1722
• Main Authors: Learmont, Jennifer C, Geczy, Andrew F, Mills, John, Ashton, Lesley J, Raynes-Greenow, Camille H, Garsia, Roger J, Dyer, Wayne B, McIntyre, Larissa, Oelrichs, Robert B, Rhodes, David I, Deacon, Nicholas J, McPhee, Dale A, Crowe, Suzanne, Solomon, Ajantha E, Chatfield, Catherine, Blasdall, Sean, Kuipers, Harmjan, Sullivan, John S
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 03.06.1999
• Subjects: Adult; Aged; Aged, 80 and over; AIDS/HIV; Biological and medical sciences; CD4 Lymphocyte Count - drug effects; Disease Progression; Female; Genes, nef; HIV Infections - immunology; HIV Infections - mortality; HIV Infections - virology; HIV Long Terminal Repeat - genetics; HIV-1 - classification; HIV-1 - genetics; HIV-1 - isolation & purification; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Longitudinal Studies; Male; Medical sciences; Middle Aged; Mutation; RNA, Viral - blood; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Human; Immunopathology; HIV-1 virus; Virological exploration; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Immunological investigation; Viral disease; Cohort study; Evolution; Human immunodeficiency virus; Attenuated strain; Lymphocyte
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199906033402203

It is well recognized that host and viral factors modify the rate at which infection with the human immunodeficiency virus type 1 (HIV-1) progresses to the acquired immunodeficiency syndrome (AIDS). Identified host factors include age 1 – 4 and genetic background. 5 – 8 The nef gene is a major determinant of virulence in primate lentiviruses. Strains of simian immunodeficiency virus (SIV) lacking the nef gene have been shown to be less pathogenic in macaques and to replicate less well in vivo than isogenic strains with an intact nef open reading frame. 9 Kirchhoff et al. reported a single case of long-term, factor VIII–transmitted, nonprogressive . . .