Intratumoral heterogeneity of DNA content in lung cancer

Heterogeneity of DNA content was analyzed in 208 samples from 20 resected lung tumors. Only one carcinoma was homogeneously diploid, but the others had DNA aneuploidy in at least some tissue samples. Eighteen tumors (90%) had varying degrees of heterogeneity of DNA content. Over half of these could...

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Bibliographic Details
Published inCancer Vol. 65; no. 10; pp. 2266 - 2269
Main Authors Carey, Francis A., Lamb, David, Bird, Colin C.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 15.05.1990
Wiley-Liss
Subjects
Adenocarcinoma - genetics
Aged
Biological and medical sciences
Carcinoid Tumor - genetics
Carcinoma - genetics
DNA, Neoplasm - analysis
Female
Flow Cytometry
Humans
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Ploidies
Pneumology
Tumors of the respiratory system and mediastinum
Human
Flow cytometry
Respiratory disease
Exploration
Histology
Malignant tumor
Bronchopulmonary
Pathology
Heterogeneity
Correlation analysis
DNA
Adult
Tumor
Elderly
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Summary:Heterogeneity of DNA content was analyzed in 208 samples from 20 resected lung tumors. Only one carcinoma was homogeneously diploid, but the others had DNA aneuploidy in at least some tissue samples. Eighteen tumors (90%) had varying degrees of heterogeneity of DNA content. Over half of these could have been mislabeled as diploid if the tumors had not been widely sampled. The importance of adequate sampling in assessing ploidy status of lung tumors is emphasized.
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19900515)65:10<2266::AID-CNCR2820651018>3.0.CO;2-R