Time-course expression profiles of hair cycle-associated genes in male mini rats after depilation of telogen-phase hairs

• Published in: International journal of molecular sciences Vol. 10; no. 5; pp. 1967 - 1977
• Main Authors: Umeda-Ikawa, Aya, Shimokawa, Isao, Doi, Kunio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.04.2009; Molecular Diversity Preservation International (MDPI)
• Subjects: Animals; dorsal skin; Follicles; Gene Expression; Gene Expression Profiling; GH-deficient Mini rats; Growth Hormone - deficiency; Growth Hormone - genetics; Growth Hormone - metabolism; Growth hormones; Hair - cytology; Hair - growth & development; Hair - physiology; hair cycle; Hair Follicle - embryology; Hair Follicle - metabolism; Hair Removal; Histology; Male; microarray analysis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Transgenic; Rats, Wistar; Skin; Skin - metabolism; Japan; dorsal skin; microarray analysis; GH-deficient Mini rats; hair cycle
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms10051967

Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents.