IgG Anti-laminin-1 Autoantibody and Recurrent Miscarriages

• Published in: American journal of reproductive immunology (1989) Vol. 45; no. 4; pp. 232 - 238
• Main Authors: INAGAKI, JUNKO, MATSUURA, EIJI, KAIHARA, KEIKO, KOBAYASHI, KAZUKO, YASUDA, TATSUJI, NOMIZU, MOTOYOSHI, SUGIURA-OGASAWARA, MAYUMI, KATANO, KINUE, AOKI, KOJI
• Format: Journal Article
• Language: English
• Published: Copenhagen Munksgaard 01.04.2001; Blackwell
• Subjects: Abortion, Habitual - etiology; Abortion, Habitual - immunology; Adhesion molecule; Adult; anti-laminin-1 antibody; antiphospholipid antibody; Autoantibodies - blood; autoantibody; Biological and medical sciences; Diseases of mother, fetus and pregnancy; Female; Gynecology. Andrology. Obstetrics; Humans; Immunoglobulin G - blood; Laminin - immunology; Medical sciences; Pregnancy; Pregnancy Trimester, First; Pregnancy. Fetus. Placenta; recurrent miscarriage; Human; Relapse; Pregnancy disorders; Cell adhesion molecule; Autoantibody; IgG; Biological marker; Phospholipid; Female; Abortion
• ISSN: 1046-7408; 1600-0897
• DOI: 10.1111/j.8755-8920.2001.450406.x

PROBLEM: The present study assesses the clinical significance of anti‐laminin‐1 auto‐antibodies (auto‐Abs) in recurrent miscarriages.
 METHOD OF STUDY: A total of 207 recurrent aborters with a history of two or more consecutive first‐trimester miscarriages were tested for the presence of anti‐laminin‐1 Abs, β2‐glycoprotein I‐dependent anticardiolipin Abs, lupus anticoagulants, anti‐DNA Abs, and anti‐nuclear Abs, before they had conceived again. Recurrent aborters then were followed up during subsequent pregnancies and their outcomes were evaluated relative to their blood test results prior to pregnancy.
 RESULTS: Fifty‐five (31.1%) women out of 177 recurrent aborters were positive for IgG anti‐laminin‐1 auto‐Abs. The levels of IgG anti‐laminin‐1 auto‐Abs in recurrent aborters were significantly higher than those in healthy pregnant women and in healthy non‐pregnant women (P=0.0043 and 0.0073, respectively). The live birth rate of subsequent pregnancies in IgG anti‐laminin‐1 auto‐Abs‐positive recurrent aborters was significantly lower than the IgG anti‐laminin‐1 auto‐Abs‐negative recurrent aborters (P=0.0320). There were no specifically significant relationships observed between IgG anti‐laminin‐1 auto‐Abs and other tested auto‐Abs.
 CONCLUSION: IgG anti‐laminin‐1 auto‐Abs are associated with recurrent miscarriages and the subsequent pregnancy outcome of recurrent aborters.