Synthesis of 5-(Fluoromethyl)-4,5-dihydroisoxazoles by Silver- Catalyzed Oxyfluorination of Unactivated Alkenes

A new silver‐catalyzed oxyfluorination of unactivated alkenes using commercially available Selectfluor as the fluorine source is presented. This method provides a new access to 5‐(fluoromethyl)‐4,5‐dihydroisoxazoles, and represents a new example of alkene 1,2‐difunctionalization by simultaneously fo...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 356; no. 14-15; pp. 2913 - 2918
Main Authors Liu, Yan-Yun, Yang, Ji, Song, Ren-Jie, Li, Jin-Heng
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 13.10.2014
WILEY‐VCH Verlag
Wiley
Subjects
Alkenes
Catalysis
Chemistry
Chemistry, Applied
Chemistry, Organic
Fluorine
Forming
isoxazoles
oxyfluorination
Physical Sciences
Science & Technology
Selectfluor
silver
Synthesis
ISOXAZOLINES
isoxazoles
alkenes
oxyfluorination
OXIMES
Selectfluor
1,3-DIPOLAR CYCLOADDITION
REGIOSELECTIVE SYNTHESIS
CHEMISTRY
CONDENSATION
silver
ALIPHATIC CARBOXYLIC-ACIDS
DERIVATIVES
EFFICIENT
PRIMARY NITRO-COMPOUNDS
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Summary:A new silver‐catalyzed oxyfluorination of unactivated alkenes using commercially available Selectfluor as the fluorine source is presented. This method provides a new access to 5‐(fluoromethyl)‐4,5‐dihydroisoxazoles, and represents a new example of alkene 1,2‐difunctionalization by simultaneously forming two new carbon‐heteroatom bonds.
Bibliography:Specialized Research Fund for the Doctoral Program of Higher Education - No. 20120161110041
ArticleID:ADSC201400242
istex:2877145EDE1C0751937278007AC753E58BAF07D2
ark:/67375/WNG-Z71CML98-Q
Hunan Provincial Natural Science Foundation of China - No. 13JJ2018
Natural Science Foundation of China - No. 21172060
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400242