Long non‐coding RNAs and prostate cancer

Long non‐coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led t...

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Published inCancer science Vol. 108; no. 11; pp. 2107 - 2114
Main Authors Misawa, Aya, Takayama, Ken‐ichi, Inoue, Satoshi
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.11.2017
John Wiley and Sons Inc
Subjects
Androgen
androgen receptor
Androgen receptors
Biomarkers
Biomarkers, Tumor - genetics
Carcinogenesis
Castration
castration resistant prostate cancer
Cell growth
Gene Expression Regulation, Neoplastic
Humans
Kinases
long non‐coding RNA
Male
Medical Overuse
Nucleotides
Prostate cancer
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Review
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Therapeutic applications
Unsolicited Review
prostate cancer
long non-coding RNA
androgen receptor
Androgen
castration resistant prostate cancer
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Summary:Long non‐coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led to overdiagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis. In particular, we focused on lncRNAs regulated by androgen receptor and expressed in castration‐resistant prostate cancer. Long non‐coding (Lnc) RNAs modulate key cellular processes in normal physiology and diseases such as cancer. In this review, expression patterns of lncRNAs in prostate cancer and mechanisms which contribute to prostate carcinogenesis have been summarized.
Bibliography:This work was supported by grants of P‐DIRECT and P‐CREATE from Ministry of Education, Culture, Sports, Science and Technology, Japan (SI); by grants (K.T. and S.I.) from JSPS (numbers 15K15581, 15K15353), Japan; by a grant from the Program for Promotion of Fundamental Studies in Health Sciences from the National Institute of Biomedical Innovation, Japan (S.I.); by Grants‐in‐Aid (S.I.) from the Ministry of Health, Labor and Welfare, Japan; and grants from the Terumo Foundation for Life Sciences and Arts (K.T.) and the NOVARTIS Foundation for the Promotion of Science, Japan (K.T.).
Funding Information
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SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1347-9032
1349-7006
1349-7006
DOI:10.1111/cas.13352