Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide

The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffectiv...

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Bibliographic Details
Published inJournal of pineal research Vol. 16; no. 4; p. 210
Main Authors Guerrero, J M, Reiter, R J, Poeggeler, B, Chen, L D, Tan, D X
Format Journal Article
LanguageEnglish
Published England 01.05.1994
Subjects
Animals
Arginine - pharmacology
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Male
Nitric Oxide - pharmacology
Nitroprusside - pharmacology
Organ Culture Techniques
Pineal Gland - drug effects
Pineal Gland - metabolism
Rats
Rats, Sprague-Dawley
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Summary:The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L-arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L-arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.
ISSN:0742-3098
DOI:10.1111/j.1600-079X.1994.tb00104.x