Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study

• Published in: JNCI : Journal of the National Cancer Institute Vol. 113; no. 3; pp. 318 - 328
• Main Authors: Helgadottir, Hildur, Isaksson, Karolin, Fritz, Ildiko, Ingvar, Christian, Lapins, Jan, Höiom, Veronica, Newton-Bishop, Julia, Olsson, Håkan
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2021; Oxford Publishing Limited (England)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Confidence intervals; Decades; Female; Follow-Up Studies; Humans; Incidence; Infant; Invasiveness; Male; Medicin och hälsovetenskap; Melanoma; Melanoma - epidemiology; Melanoma, Cutaneous Malignant; Men; Middle Aged; Population studies; Population-based studies; Registries; Skin Neoplasms - epidemiology; Statistical analysis; Sweden - epidemiology; Trends; Women; Young Adult; Sweden
• ISSN: 0027-8874; 1460-2105; 1460-2105
• DOI: 10.1093/jnci/djaa088

Abstract Background Over the past decades, many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma. Methods In this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry were followed for up to 10 years for a diagnosis of subsequent primary melanoma. Patients were grouped with patients diagnosed with first melanoma in the same decade (1960s, 1970s, 1980s, 1990s, and 2000s, respectively). Frequencies, incidence rates (IRs), standardized incidence ratios (SIRs), and 95% confidence intervals (CIs) for second melanomas were calculated. All tests of statistical significance were 2-sided. Results Of patients with melanoma, 54 884 were included and 2469 were diagnosed, within 10 years, with subsequent melanomas. Over the 5 decades, there was a statistically significant steady increase in the frequency, IR, and SIR for second primary melanoma. For example, in the 1960s cohort, less than 1% (IR = 1.0, 95% CI = 0.5 to 1.7, and IR = 1.1, 95% CI = 0.5 to 1.9 per 1000 person-years in women and men, respectively) had second primary melanoma, and this rose to 6.4% (IR = 7.5, 95% CI = 6.8 to 8.3, per 1000 person-years) in the women and 7.9% (IR = 10.3, 95% CI = 9.3 to 11.2, per 1000 person-years) in the men in the 2000s cohort. This rise was seen independent of age, sex, invasiveness, or site of the melanoma. Further, in patients diagnosed with a second melanoma, the frequency of those having more than 2 melanomas increased statistically significantly and was 0.0% in the 1960s and rose to 18.0% in the 2000s (P < .001). Conclusions This is the first study to evaluate and report on a rising trend for subsequent primary melanoma. Additional primary melanomas worsen the patients’ survival, and precautions are needed to turn this steep upgoing trend.