Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

• Published in: Biomaterials Vol. 35; no. 10; pp. 3365 - 3383
• Main Authors: Naksuriya, Ornchuma, Okonogi, Siriporn, Schiffelers, Raymond M., Hennink, Wim E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2014
• Subjects: Advanced Basic Science; anti-inflammatory activity; antineoplastic agents; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; antioxidants; Cancer; Chemistry, Pharmaceutical; Clinical studies; clinical trials; Curcuma longa; Curcumin; Curcumin - chemistry; Curcumin - pharmacology; Curcumin - therapeutic use; cyclodextrins; Dentistry; dispersions; Drug Carriers; Drug delivery; emulsions; glycemic effect; herbs; humans; lipids; Micelles; myocardial infarction; Nanoformulation; Nanomedicine; nanoparticles; Nanostructures; neoplasms; nephroprotective effect; Pharmaceutical Preparations - chemistry; Polymers - chemistry; solubility; thrombosis; turmeric; Curcumin; Drug delivery; Nanomedicine; Clinical studies; Cancer; Nanoformulation
• ISSN: 0142-9612; 1878-5905; 1878-5905
• DOI: 10.1016/j.biomaterials.2013.12.090

Curcumin, a natural yellow phenolic compound, is present in many kinds of herbs, particularly in Curcuma longa Linn. (turmeric). It is a natural antioxidant and has shown many pharmacological activities such as anti-inflammatory, anti-microbial, anti-cancer, and anti-Alzheimer in both preclinical and clinical studies. Moreover, curcumin has hepatoprotective, nephroprotective, cardioprotective, neuroprotective, hypoglycemic, antirheumatic, and antidiabetic activities and it also suppresses thrombosis and protects against myocardial infarction. Particularly, curcumin has demonstrated efficacy as an anticancer agent, but a limiting factor is its extremely low aqueous solubility which hampers its use as therapeutic agent. Therefore, many technologies have been developed and applied to overcome this limitation. In this review, we summarize the recent works on the design and development of nano-sized delivery systems for curcumin, including liposomes, polymeric nanoparticles and micelles, conjugates, peptide carriers, cyclodextrins, solid dispersions, lipid nanoparticles and emulsions. Efficacy studies of curcumin nanoformulations using cancer cell lines and in vivo models as well as up-to-date human clinical trials are also discussed.