TRAIL gene 1595C/T polymorphisms contribute to the susceptibility and severity of intervertebral disc degeneration: a data synthesis

• Published in: BMC musculoskeletal disorders Vol. 18; no. 1; p. 555
• Main Authors: Yuan, Qi-Ling, Liu, Liang, Cai, Yong-Song, Zhang, Yin-Gang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.12.2017; BioMed Central; BMC
• Subjects: Apoptosis; Asian Continental Ancestry Group - genetics; Case-Control Studies; Disease susceptibility; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Humans; Intervertebral disc degeneration; Intervertebral Disc Degeneration - diagnosis; Intervertebral Disc Degeneration - epidemiology; Intervertebral Disc Degeneration - genetics; Meta-analysis; Physiological aspects; Polymorphism, Single Nucleotide - genetics; Polymorphisms; Severity of Illness Index; Statistics as Topic - methods; TNF-Related Apoptosis-Inducing Ligand - genetics; TRAIL gene; Tumor necrosis factor; Intervertebral disc degeneration; TRAIL gene; Polymorphisms; Meta-analysis
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-017-1916-3

Studies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD), but the results were inconsistent. To evaluate the specific relationship, we performed a meta-analysis to clarify the controversies. Four databases were searched, and the pooled results were presented as odds ratios (ORs) with 95% confidence intervals (CIs). Three case-control studies from Han Chinese were included (565 cases and 427 controls). All the included studies reported TRAIL 1595C/T gene polymorphisms. The recessive model (CC vs. CT + TT) was the optimal model, which demonstrated a significant relationship between 1595C/T polymorphisms and increased IDD risk (OR = 2.18, 1.45 to 3.27, P = 0.000). No significant heterogeneity was found in the recessive model (I  = 48.6%, P = 0.143). Patients with lower grade IDD had more genotypes or alleles including 1595TT genotype (grade II vs. grade III: OR = 2.12, 1.18 to 3.83, P = 0.012; grade III vs. grade IV: OR = 2.59, 1.29 to 5.22, P = 0.007) and 1595 T allele (grade II vs. grade III: OR = 1.91, 1.43 to 2.55, P = 0.000; grade II vs. grade IV: OR = 2.46, 0.94 to 1.76, P = 0.000). There is a significant relationship between 1595C/T polymorphisms and the susceptibility and severity of IDD in Han Chinese. Patients with lower grade IDD had higher frequency of the 1595TT genotype and 1595 T allele.