Comparison of different endoscopic resection techniques for submucosal tumors originating from muscularis propria at the esophagogastric junction

• Published in: BMC gastroenterology Vol. 19; no. 1; p. 174
• Main Authors: Xu, Hong-Wei, Zhao, Qi, Yu, Shu-Xia, Jiang, Ying, Hao, Jing-Hua, Li, Bin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.11.2019; BioMed Central; BMC
• Subjects: Adult; Care and treatment; Comparative analysis; Endoscopic Mucosal Resection - adverse effects; Endoscopic Mucosal Resection - methods; Endoscopic submucosal excavation; Endoscopy; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophagogastric junction; Esophagogastric Junction - pathology; Esophagogastric Junction - surgery; Female; Humans; Male; Medical research; Methods; Middle Aged; Muscularis propria; Operative Time; Political aspects; Postoperative Complications; Recurrence (Disease); Retrospective Studies; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Submucosal tumor; Submucosal tunneling endoscopic resection; Surgery; Tumors; Endoscopic submucosal excavation; Submucosal tunneling endoscopic resection; Submucosal tumor; Esophagogastric junction; Muscularis propria
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-019-1099-5

To compare the outcomes of submucosal tunneling endoscopic resection (STER) and submucosal excavation (ESE) for the treatment of submucosal tumors (SMTs) arising from the muscularis propria (MP) at the esophagogastric junction (EGJ). A retrospective analysis of patients with SMTs at EGJ who underwent STER and ESE from October 2011 to October 2017 was performed. The outcomes evaluated were operation time, complete resection rate, adverse events, and tumor recurrence. Ninety patients were included in this study. Complete resection rates in the STER group were higher than those of the ESE group (100 vs. 92%, p < 0.05). For tumors ≤15 mm, both techniques achieved 100% complete resection rate; but for tumors > 15 mm, complete resection rate was higher in the STER group than the ESE group (100% vs. 77.8%, p < 0.05). Subgroup analyses revealed that the operation time of STER for in cardiac-gastric group was longer than that for ESE (145.14 ± 42.43 min vs. 70.32 ± 39.84 min, p <  0.05). The air leakage symptoms were more frequent in STER group (90.9% vs. 50.0%, p < 0.05). No tumor recurrence occurred in both the STER and ESE groups. For SMTs ≤15 mm, both STER and ESE have similar satisfactory therapeutic outcomes. However, in the cardiac-gastric subgroup, STER had a longer operative time compared to the ESE procedure. For SMTs > 15 mm, STER is the preferred choice due to its higher complete resection rate.