Sch 37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES
A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs...
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| Published in | Journal of antibiotics Vol. 41; no. 1; pp. 13 - 19 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
01.01.1988
Japan Antibiotics Research Association |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs ≥128μg/ml) in Sabouraud dextrose, yeastnitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs ≥12μg/ml) and dermatophytes (mean MICs ≥0.8μg/ml) significantly improved in MA medium. |
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| AbstractList | A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs greater than or equal to 128 micrograms/ml) in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs greater than or equal to 12 micrograms/ml) and dermatophytes (mean MICs greater than or equal to 0.8 microgram/ml) significantly improved in MA medium. A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs ≥128μg/ml) in Sabouraud dextrose, yeastnitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs ≥12μg/ml) and dermatophytes (mean MICs ≥0.8μg/ml) significantly improved in MA medium. A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. The compound was weakly active against species of Candida and dermatophytes in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. and dermatophytes significantly improved in MA medium. |
| Author | LOEBENBERG, DAVID TRUUMEES, IMBI MARQUEZ, JOSEPH GULLO, VINCENT HORAN, ANN C. PUAR, MOHINDAR S. COOPER, RAYMOND PATEL, MAHESH GENTILE, FRANK |
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| Keywords | Fungi Antifungal agent Molecular structure Taxonomy Production Isolation Fermentation Biological activity Physicochemical properties Thallophyta |
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| References | 5) KINOSHITA, T.; Y. KASAHARA & N. NIMURA: Reversed phase high performance liquid chromatographic resolution of non esterified enantiomeric amino acids by derivatization with 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate and 2,3,4-tri-O-acetyl-β-D-arabinose pyranosyl isothiocyanate. J. Chromatogr. 210: 77-81, 1981 12) ACHENBACH, H.; A. MUHLENFELD, U. FAUTH & H. ZAHNER: Galbonolides A and B - two new non-glycosidic antifungal macrolides from Streptomyces galbus. Tetrahedron Lett. 26: 6167 - 6170, 1985 2) SKIRLING, E. B. & D. GOTTLIEB: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966 13) FAUTH, U.; H. ZAHNER, A. MUHLENFELD & H. ACHENBACH: Galbonolides A and B - Two non-glycosidic antifungal macrolides. J. Antibiotics 39: 1760-1764, 1986 3) LECHEVALIER, M. P.: Identification of aerobic actinomycetes of clinical importance. J. Lab. Clin. Med. 71:934-944,1968 9) MILEWSKI, S.; H. CHMARA & E. BOROWSKI: Growth inhibitory effect of antibiotic tetaine on yeast and mycelial forms of Candida albicans. Arch. Microbiol. 135: 130-136, 1983 8) ANDRUSZKIEWICZ, R.; H. CHMARA & E. BOROWSKI: Anticandidal activity of antibiotic A 19009 and its isomer. J. Antibiotics 37: 1479-1482, 1984 6) JACKMAN, L. M. & S. STERNHALL (Ed.): Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry. 2nd Ed. p. 224, Pergamon Press, New York, 1969 7) VAN DER BAAN, J. L.; J. W. F. K. BARNICK & F. BICKELHAUPT: Antibiotic A 19009. Structural investigation and synthesis. J. Antibiotics 36: 784-792, 1983 10) TAKATSU, T.; H. NAKAYAMA, A. SHIMAZU, K. FURIHATA, K. IKEDA, K. FURIHATA, H. SETO & N. OTAKE: Rustmicin, a new macrolide antibiotic active against wheat stem rust fungus. J. Antibiotics 38: 1806-1809, 1985 11) ABE, Y.; H. NAKAYAMA, A. SHIMAZU, K. FURIHATA, K. IKEDA, K. FURIHATA, H. SETO & N. OTAKE: Neorustmicin A, a new macrolide antibiotic active against wheat stem rust fungus. J. Antibiotics 38: 1810-1812, 1985 4) The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. 10th Ed. Ed., M. WINDHOLZ, Merck & Co., Inc., Rahway, 1983 1) MOLLOY, B. B.; D. H. LIVELY, R. M. GALE, M. GORMAN, L. D. BOECK, C. E. HIGGENS, R. E. KASTNER, L. L. HUCKSTEP & N. NEUSS: A new dipeptide antibiotic from Streptomyces collinus, LINDENBEIN. J. Antibiotics 25: 137-140, 1972 |
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| Snippet | A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a... A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. The compound was weakly active against species of... |
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| SubjectTerms | Amino Acids, Diamino - biosynthesis Amino Acids, Diamino - pharmacology Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - biosynthesis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Biological and medical sciences Biotechnology Chemical Phenomena Chemistry Fermentation Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Medical sciences Micromonospora Micromonospora - metabolism Pharmacology. Drug treatments Production of active biomolecules |
| Subtitle | TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES |
| Title | Sch 37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP |
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